Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.88 |
| ▸ | TFEB | P19484 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | BCHE | P06276 | 1/20 | 0.63 |
| ▸ | BACE1 | P56817 | 2/20 | 0.57 |
| ▸ | APP | P05067 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.56 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.56 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 3/20 | 0.55 |
| ▸ | AR | P10275 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414394 | 1.00 | NFE2L2 (0.88) | NFE2L2TFEBKDM4EMAPTNPC1 | |
| SCHEMBL5598851 | 0.94 | NFE2L2 (1.00) | NFE2L2TFEBKDM4EMAPTNPC1 | |
| SCHEMBL5598849 | 0.94 | NFE2L2 (1.00) | NFE2L2TFEBKDM4EMAPTNPC1 | |
| SCHEMBL10667607 | 0.88 | NFE2L2 (0.88) | NFE2L2TFEBKDM4EMAPTNPC1 | |
| SCHEMBL10667601 | 0.88 | NFE2L2 (0.88) | NFE2L2TFEBKDM4EMAPTNPC1 | |
| SCHEMBL7415412 | 0.87 | NFE2L2 (0.89) | NFE2L2KDM4EMAPTNPC1LMNA | |
| SCHEMBL7415405 | 0.87 | NFE2L2 (0.89) | NFE2L2KDM4EMAPTNPC1LMNA | |
| SCHEMBL2623834 | 0.84 | NFE2L2 (0.81) | NFE2L2TFEBKDM4EMAPTNPC1 | |
| SCHEMBL17691543 | 0.84 | NFE2L2 (0.80) | NFE2L2TFEBKDM4EMAPTNPC1 | |
| SCHEMBL10756384 | 0.82 | NFE2L2 (0.78) | NFE2L2TFEBKDM4EMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0126094-B1 | NEW 1,4-DIHYDROPYRIDINE ESTERS AND PREPARATION METHODS THEREOF AND DRUGS CONTAINING SAID ESTERS | CERMOL S.A. (CH) | 1990-06-20 | — | — | EP | disclosed |
| EP-0126094-A1 | NEW 1,4-DIHYDROPYRIDINE ESTERS AND PREPARATION METHODS THEREOF AND DRUGS CONTAINING SAID ESTERS. | CERMOL SA (CH) | 1984-11-28 | — | — | EP | disclosed |
| WO-1984002132-A1 | NEW 1,4-DIHYDROPYRIDINE ESTERS AND PREPARATION METHODS THEREOF AND DRUGS CONTAINING SAID ESTERS | CERMOL SA (CH) | 1984-06-07 | — | — | WO | disclosed |