Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10666873 | 0.87 | ALOX15 (0.46) | ALOX15NPC1RAB9ATDP1TMEM97 | |
| Hydrochloric Acid SCHEMBL10670773 | 0.86 | NPC1 (0.46) | ALOX15NPC1RAB9ATDP1TMEM97 | |
| SCHEMBL10671097 | 0.82 | PTGES (0.46) | ALOX15TMEM97SIGMAR1GAAKDM4E | |
| SCHEMBL10666343 | 0.82 | PDE4A (0.44) | ALOX15TMEM97SIGMAR1GAAKDM4E | |
| Hydrochloric Acid SCHEMBL10670397 | 0.81 | PTGES (0.45) | ALOX15TMEM97SIGMAR1GAAKDM4E | |
| Hydrochloric Acid SCHEMBL10673349 | 0.81 | PTGES (0.43) | ALOX15TMEM97SIGMAR1GAAKDM4E | |
| SCHEMBL12767048 | 0.80 | POLB (0.54) | ALOX15POLBNPC1RAB9AKMT2A | |
| SCHEMBL1499550 | 0.80 | TSHR (0.58) | POLBNPC1RAB9ATDP1KMT2A | |
| SCHEMBL13116734 | 0.77 | ALOX15 (0.61) | ALOX15POLBNPC1RAB9ASIGMAR1 | |
| SCHEMBL8299753 | 0.76 | TDP1 (0.68) | POLBNPC1RAB9ATDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288201-A1 | Process for the preparation of benzodiazepines | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-10-26 | — | — | EP | disclosed |
| US-4749788-A | Process for the preparation of aryl-pyrido(1,4) benzodiazepines | A. H. ROBINS COMPANY, INCORPORATED (US) | 1988-06-07 | — | — | US | disclosed |