SCHEMBL10669013

SCHEMBL10669013

CC(C)(C)c1ccc(O)c(-n2nc3cc(Cl)c(Cl)cc3n2)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.45
RAB9A P51151 3/20 0.45
LMNA P02545 3/20 0.45
ALDH1A1 P00352 5/20 0.44
HPGD P15428 3/20 0.44
TDP1 Q9NUW8 2/20 0.44
ALOX15 P16050 2/20 0.44
HSD17B10 Q99714 2/20 0.44
KMT2A Q03164 4/20 0.41
MEN1 O00255 3/20 0.41
MAPT P10636 3/20 0.41
GAA P10253 1/20 0.41
PKM P14618 1/20 0.41
RECQL P46063 1/20 0.41
SMN1; SMN2 Q16637 5/20 0.36
CYP2D6 P10635 2/20 0.36
KDM4E B2RXH2 3/20 0.36
MITF O75030 1/20 0.36
KLF5 Q13887 1/20 0.36
HSP90AA1 P07900 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29814292 0.87 NPC1 (0.46) NPC1RAB9ALMNAALDH1A1HPGD
SCHEMBL351147 0.87 NPC1 (0.46) NPC1RAB9ALMNAALDH1A1HPGD
SCHEMBL29354646 0.84 NPC1 (0.64) NPC1RAB9ALMNAALDH1A1HPGD
SCHEMBL78159 0.84 NPC1 (0.64) NPC1RAB9ALMNAALDH1A1HPGD
SCHEMBL9291089 0.83 PLG (0.38) NPC1RAB9ALMNAALDH1A1HPGD
SCHEMBL3381528 0.81 MEN1 (0.57) NPC1RAB9ALMNAALDH1A1HPGD
SCHEMBL30887107 0.81 MEN1 (0.57) NPC1RAB9ALMNAALDH1A1HPGD
SCHEMBL27481690 0.81 NPC1 (0.46) NPC1RAB9ALMNAALDH1A1HPGD
SCHEMBL29813507 0.80 NPC1 (0.71) NPC1RAB9ALMNAALDH1A1HPGD
SCHEMBL561850 0.80 NPC1 (0.71) NPC1RAB9ALMNAALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4755546-A Stabilized olefin polymers BORG-WARNER CHEMICALS, INC. (US) 1988-07-05 US disclosed
US-4668722-A Hindered piperidinoalcohol 1,1,1-trioxyalkane stabilizers MACK GERRY P 1987-05-26 US disclosed
US-4501838-A WITH ESTER OF PENTAERYTHRITOL MONOACETATE BORG-WARNER CHEMICALS, INC. (US) 1985-02-26 US disclosed
US-4298520-A PHOSPHITES OR PHOSPHATES ARGUS CHEMICAL CORP. (US) 1981-11-03 US disclosed
US-4293472-A O-ALKYLHYDROXYBENZYLPROPANE-1,3-DIOL ESTERS CONTAINING SULFIDE GROUPS ADEKA ARGUS CHEMICAL CO., LTD. 1981-10-06 US disclosed
US-4257927-A Inorganic organic coester stabilizers ARGUS CHEMICAL CORP. (US) 1981-03-24 US disclosed
US-4255301-A HEAT RESISTANCE, PHOTOSTABILITY ARGUS CHEMICAL CORPORATION (US) 1981-03-10 US disclosed
US-4233414-A FOR SYNTHETIC RESINS HEAT RESISTANCE ARGUS CHEMICAL CORPORATION (US) 1980-11-11 US disclosed
US-4225474-A Organophosphonate coester stabilizers ARGUS CHEMICAL CORP. (US) 1980-09-30 US disclosed
US-4199495-A Thiolcarbonate ester stabilizers ARGUS CHEMICAL CORP. (US) 1980-04-22 US disclosed
EP-0006842-A1 Organophosphonate co-ester, stabiliser composition containing it and synthetic resin stabilised therewith S.A. Diamond Shamrock Benelux N.V. (BE) 1980-01-23 EP disclosed
US-4174297-A Polyhydric phenol coester stabilizers ARGUS CHEMICAL CORPORATION (US) 1979-11-13 US disclosed
US-4171298-A SUBSTITUTED ORTHO-ALKYLHYDROXYBENZYLPROPANE-1,3-DIOL ESTERS ARGUS CHEMICAL CORPORATION (US) 1979-10-16 US disclosed
US-4146517-A FOR SYNTHETIC RESINS AGAINST HEAT ARGUS CHEMICAL CORPORATION (US) 1979-03-27 US disclosed
US-4104217-A OF POLYHYDRIC PHENOLS ARGUS CHEMICAL CORPORATION (US) 1978-08-01 US disclosed