Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 7/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.36 |
| ▸ | METAP1 | P53582 | 2/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 5/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10675633 | 1.00 | CRBN (0.37) | CRBNCSNK1A1METAP1PARP10PARP11 | |
| SCHEMBL10378861 | 0.85 | HTT (0.41) | CRBNMETAP1SRD5A1HTR2AHTR2C | |
| SCHEMBL10689726 | 0.85 | CRBN (0.37) | CRBNSRD5A1HTR2AHTR2CHTR2B | |
| SCHEMBL10689731 | 0.85 | CRBN (0.37) | CRBNSRD5A1HTR2AHTR2CHTR2B | |
| SCHEMBL10378860 | 0.85 | HTT (0.41) | CRBNMETAP1SRD5A1HTR2AHTR2C | |
| SCHEMBL10692994 | 0.82 | SRD5A1 (0.41) | CRBNCSNK1A1METAP1PARP10PARP11 | |
| SCHEMBL10378790 | 0.81 | CRBN (0.46) | CRBNACHE | |
| SCHEMBL10378789 | 0.81 | CRBN (0.46) | CRBNACHE | |
| SCHEMBL10688845 | 0.79 | CRBN (0.36) | CRBN | |
| SCHEMBL10686557 | 0.77 | CRBN (0.39) | CRBNCSNK1A1METAP1PARP10IKZF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4670562-A | MEMORY ENHANCEMENT | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-06-02 | — | — | US | claimed |
| US-4742171-A | AROMATIZATION, REARRANGEMENT | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-05-03 | — | — | US | disclosed |
| US-4742061-A | Benzoc[c]-1,5-naphthyridines and related compounds as memory enhancing agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-05-03 | — | — | US | disclosed |
| US-4670562-A | MEMORY ENHANCEMENT | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-06-02 | — | — | US | disclosed |
| US-4652567-A | Benzo(c)-1,5-naphthyridines useful for treating a patient having drug induced memory impairment in need of memory enhancement | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-03-24 | — | — | US | disclosed |