Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 11/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HPN | P05981 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10356732 | 0.89 | VCAM1 (0.46) | VCAM1PTGS1TDP1HPNMAPT | |
| SCHEMBL9347028 | 0.86 | VCAM1 (0.52) | VCAM1PTGS1TDP1HPNMAPT | |
| SCHEMBL9328168 | 0.86 | PTGS1 (0.61) | VCAM1PTGS1TDP1HPNMAPT | |
| SCHEMBL9163619 | 0.81 | VCAM1 (0.50) | VCAM1PTGS1TDP1HPNMAPT | |
| SCHEMBL646924 | 0.78 | ALOX15 (0.63) | VCAM1PTGS1TDP1HPNMAPT | |
| SCHEMBL9550716 | 0.77 | HPN (0.47) | VCAM1PTGS1TDP1HPNMAPT | |
| SCHEMBL7699048 | 0.77 | VCAM1 (0.56) | VCAM1PTGS1TDP1HPNMAPT | |
| SCHEMBL9014627 | 0.76 | HPN (0.46) | VCAM1PTGS1TDP1HPNMAPT | |
| SCHEMBL9163368 | 0.76 | HPN (0.46) | VCAM1TDP1HPNMAPTALOX15 | |
| SCHEMBL11190923 | 0.76 | VCAM1 (0.48) | VCAM1PTGS1TDP1HPNMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4755524-A | Novel phenolic thioethers as inhibitors of 5-lipoxygenase | G. D. SEARLE & CO. (US) | 1988-07-05 | — | — | US | disclosed |
| US-4711903-A | ANTIINFLAMMATORY, ANTIALLERGY AGENTS | G. D. SEARLE & CO. (US) | 1987-12-08 | — | — | US | disclosed |
| EP-0235575-A1 | Novel phenolic thioethers as inhibitors of 5-lipoxygenase | G.D. Searle & Co. (US) | 1987-09-09 | — | — | EP | disclosed |