Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 8/20 | 0.79 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.79 |
| ▸ | NCOR1 | O75376 | 6/20 | 0.79 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.79 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.79 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.79 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.67 |
| ▸ | ABL1 | P00519 | 4/20 | 0.61 |
| ▸ | PRKCA | P17252 | 3/20 | 0.61 |
| ▸ | BCR | P11274 | 2/20 | 0.61 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.55 |
| ▸ | VCP | P55072 | 1/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27720667 | 0.90 | HDAC3 (0.64) | HDAC3HDAC2NCOR1HDAC1HDAC6 | |
| SCHEMBL29784912 | 0.89 | HDAC3 (0.77) | HDAC3HDAC2NCOR1HDAC1HDAC6 | |
| SCHEMBL1065202 | 0.87 | HDAC3 (0.74) | HDAC3HDAC2NCOR1HDAC1HDAC6 | |
| SCHEMBL13863956 | 0.87 | HDAC3 (0.77) | HDAC3HDAC2NCOR1HDAC1HDAC6 | |
| SCHEMBL27782645 | 0.86 | HDAC3 (0.69) | HDAC3HDAC2NCOR1HDAC1HDAC6 | |
| SCHEMBL210643 | 0.84 | HDAC1 (0.66) | HDAC3HDAC2NCOR1HDAC1HDAC6 | |
| SCHEMBL210190 | 0.84 | ABL1 (0.76) | HDAC1ABL1PRKCABCRPRKCD | |
| SCHEMBL19015114 | 0.84 | HDAC3 (0.69) | HDAC3HDAC2NCOR1HDAC1HDAC6 | |
| SCHEMBL4082083 | 0.83 | ABL1 (0.75) | HDAC3HDAC2HDAC1HDAC6HDAC8 | |
| Hydrochloric Acid SCHEMBL7470853 | 0.82 | ABL1 (0.74) | HDAC1ABL1PRKCABCRPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015006875-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED PYRIMIDINES | METHYLGENE INC. (US) | 2015-01-22 | — | — | WO | disclosed |
| US-7868205-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7868205-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7868205-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-20080132503-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2008-06-05 | — | — | US | disclosed |
| US-20080132503-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2008-06-05 | — | — | US | disclosed |
| US-20080132459-A1 | Inhibitors of Histone Deacetylase | METHYLGENE, INC. (CA) | 2008-06-05 | — | — | US | disclosed |
| US-20080132459-A1 | Inhibitors of Histone Deacetylase | METHYLGENE, INC. (CA) | 2008-06-05 | — | — | US | disclosed |
| US-20080132459-A1 | Inhibitors of Histone Deacetylase | METHYLGENE, INC. (CA) | 2008-06-05 | — | — | US | disclosed |
| EP-1663953-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005030705-A9 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2006-04-20 | — | — | WO | disclosed |
| WO-2005030704-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2005-04-07 | — | — | WO | disclosed |
| WO-2005030704-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2005-04-07 | — | — | WO | disclosed |
| WO-2005030705-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2005-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132459-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC3 | HDAC3 3/4885HDAC2 5/4885NCOR1 126/4885 |
| US-20080132503-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC3 | HDAC3 3/4885HDAC2 5/4885NCOR1 126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.