⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170407 | 1.00 | — | — | |
| SCHEMBL14603804 | 1.00 | — | — | |
| SCHEMBL10599712 | 0.89 | L3MBTL1 (0.35) | — | |
| SCHEMBL29134621 | 0.82 | HTT (0.31) | — | |
| SCHEMBL29475802 | 0.77 | MEN1 (0.35) | — | |
| SCHEMBL18231654 | 0.74 | — | — | |
| SCHEMBL12683411 | 0.74 | — | — | |
| SCHEMBL12683410 | 0.74 | — | — | |
| SCHEMBL31145894 | 0.73 | — | — | |
| SCHEMBL1027078 | 0.73 | CRBN (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159564-A1 | 2-Oxo-Thiazole Derivatives as A2A Inhibitors and Compounds for Use in the Treatment of Cancers | iTeos Belgium SA (BE) | 2023-05-25 | — | — | US | disclosed |
| CN-115991679-A | 2-oxothiazole derivatives as A2A inhibitors and compounds for the treatment of cancer | 伊忒欧斯比利时股份公司 | 2023-04-21 | — | — | CN | disclosed |
| CN-115873022-A | 2-oxothiazole derivatives as A2A inhibitors and compounds for the treatment of cancer | 伊忒欧斯比利时股份公司 | 2023-03-31 | — | — | CN | disclosed |
| US-20230067159-A1 | ROR-GAMMA-T INHIBITOR, PREPARATION METHOD THEREOF AND USE THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2023-03-02 | — | — | US | disclosed |
| CN-110678472-B | 2-oxothiazole derivatives as A2A inhibitors and compounds for the treatment of cancer | 伊忒欧斯比利时股份公司 | 2023-01-24 | — | — | CN | disclosed |
| EP-4112623-A1 | 2-OXO-THIAZOLE DERIVATIVES AS A2A INHIBITORS AND COMPOUNDS FOR USE IN THE TREATMENT OF CANCERS | iTeos Belgium SA (BE) | 2023-01-04 | — | — | EP | disclosed |
| EP-4089079-A1 | ROR GAMMA T INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Sunshine Lake Pharma Co., Ltd. (CN) | 2022-11-16 | — | — | EP | disclosed |
| EP-3601296-B1 | 2-OXO-THIAZOLE DERIVATIVES AS A2A INHIBITORS AND COMPOUNDS FOR USE IN THE TREATMENT OF CANCERS | iTeos Belgium SA (BE) | 2022-05-25 | — | — | EP | disclosed |
| WO-2021139599-A1 | RORγT INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 东莞市东阳光新药研发有限公司 | 2021-07-15 | — | — | WO | disclosed |
| CN-113072476-A | ROR gamma t inhibitor and preparation method and application thereof | 广东东阳光药业有限公司 | 2021-07-06 | — | — | CN | disclosed |
| WO-2018178338-A1 | 2-OXO-THIAZOLE DERIVATIVES AS A2A INHIBITORS AND COMPOUNDS FOR USE IN THE TREATMENT OF CANCERS | ITEOS THERAPEUTICS (BE) | 2018-10-04 | — | — | WO | disclosed |
| US-9505769-B2 | Tetraaza-cyclopenta[a]indenyl derivatives | ASCENEURON SA (CH) | 2016-11-29 | — | — | US | disclosed |
| US-20160137648-A1 | TETRAAZA-CYCLOPENTA[A]INDENYL DERIVATIVES | ASCENEURON SA (CH) | 2016-05-19 | — | — | US | disclosed |
| EP-3008068-A1 | TETRAAZA-CYCLOPENTA[A]INDENYL DERIVATIVES | Asceneuron SA (CH) | 2016-04-20 | — | — | EP | disclosed |
| US-8933116-B2 | Gamma secretase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-01-13 | — | — | US | disclosed |
| WO-2014198808-A1 | TETRAAZA-CYCLOPENTA[A]INDENYL DERIVATIVES | ASCENEURON SA (CH) | 2014-12-18 | — | — | WO | disclosed |
| EP-2813505-A1 | Tetraaza-cyclopenta[a]indenyl derivatives | Asceneuron SA (CH) | 2014-12-17 | — | — | EP | disclosed |
| US-20140018342-A1 | GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME LLC | 2014-01-16 | — | — | US | disclosed |
| US-4762827-A | BACTERICIDES, ANTIBIOTICS | SCHERING CORPORATION (US) | 1988-08-09 | — | — | US | disclosed |
| EP-0257602-A1 | (5R,6S,8R)-6-(1-hydroxyethyl)-2-(3R-pyrolidin-2-one-3-yl-)thiopenem-3-carboxylic acid | SCHERING CORPORATION (US) | 1988-03-02 | — | — | EP | disclosed |