⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14603804 | 1.00 | — | — | |
| SCHEMBL10679088 | 1.00 | — | — | |
| SCHEMBL10599712 | 0.89 | L3MBTL1 (0.35) | — | |
| SCHEMBL29134621 | 0.82 | HTT (0.31) | — | |
| SCHEMBL29475802 | 0.77 | MEN1 (0.35) | — | |
| SCHEMBL18231654 | 0.74 | — | — | |
| SCHEMBL12683411 | 0.74 | — | — | |
| SCHEMBL12683410 | 0.74 | — | — | |
| SCHEMBL31145894 | 0.73 | — | — | |
| SCHEMBL1027078 | 0.73 | CRBN (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114989140-B | Benzimidazole derivatives as ERBB tyrosine kinase inhibitors for the treatment of cancer | 卡佩拉医疗公司 | 2025-03-25 | — | — | CN | disclosed |
| US-20250092028-A1 | BENZIMIDAZOLE DERIVATIVES AS ERBB TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER | CAPELLA THERAPEUTICS, INC. | 2025-03-20 | — | — | US | disclosed |
| CN-114940673-B | Benzimidazole derivatives as ERBB tyrosine kinase inhibitors for the treatment of cancer | 卡佩拉医疗公司 | 2025-03-18 | — | — | CN | disclosed |
| CN-116997548-A | HTT modulators for the treatment of huntington's disease | CHDI基金会股份有限公司 | 2023-11-03 | — | — | CN | disclosed |
| US-11787788-B2 | Benzimidazole derivatives, and pharmaceutical compositions and methods of use thereof | CAPELLA THERAPEUTICS, INC. (US) | 2023-10-17 | — | — | US | disclosed |
| US-11787788-B2 | Benzimidazole derivatives, and pharmaceutical compositions and methods of use thereof | CAPELLA THERAPEUTICS, INC. (US) | 2023-10-17 | — | — | US | disclosed |
| US-11787788-B2 | Benzimidazole derivatives, and pharmaceutical compositions and methods of use thereof | CAPELLA THERAPEUTICS, INC. (US) | 2023-10-17 | — | — | US | disclosed |
| US-20230271938-A1 | BENZIMIDAZOLES FOR USE IN THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | CAPELLA THERAPEUTICS, INC. | 2023-08-31 | — | — | US | disclosed |
| US-20230271938-A1 | BENZIMIDAZOLES FOR USE IN THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES | CAPELLA THERAPEUTICS, INC. | 2023-08-31 | — | — | US | disclosed |
| US-20230159564-A1 | 2-Oxo-Thiazole Derivatives as A2A Inhibitors and Compounds for Use in the Treatment of Cancers | iTeos Belgium SA (BE) | 2023-05-25 | — | — | US | disclosed |
| WO-2015135461-A1 | SUBSTITUTED DIHYDROBENZOFURAN-PIPERIDINE-KETONE DERIVATIVE, PREPARATION AND USE THEREOF | 四川海思科制药有限公司 | 2015-09-17 | — | — | WO | disclosed |
| EP-2731940-B1 | 4 - PIPERIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-19 | — | — | EP | disclosed |
| US-20150126513-A1 | 4-PIPERIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS | NOVARTIS AG (CH) | 2015-05-07 | — | — | US | disclosed |
| WO-2014198808-A1 | TETRAAZA-CYCLOPENTA[A]INDENYL DERIVATIVES | ASCENEURON SA (CH) | 2014-12-18 | — | — | WO | disclosed |
| EP-2813505-A1 | Tetraaza-cyclopenta[a]indenyl derivatives | Asceneuron SA (CH) | 2014-12-17 | — | — | EP | disclosed |
| EP-2731940-A1 | 4 - PIPERIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS | Novartis AG (CH) | 2014-05-21 | — | — | EP | disclosed |
| WO-2013008217-A1 | 4 - PIPERIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS | NOVARTIS AG (CH) | 2013-01-17 | — | — | WO | disclosed |
| EP-2346870-A1 | 18F-LABELLED FOLATES AS PET RADIOTRACERS | Merck & Cie (CH) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010040854-A1 | 18F-LABELLED FOLATES AS PET RADIOTRACERS | MERCK EPROVA AG (CH) | 2010-04-15 | — | — | WO | disclosed |
| EP-0257602-A1 | (5R,6S,8R)-6-(1-hydroxyethyl)-2-(3R-pyrolidin-2-one-3-yl-)thiopenem-3-carboxylic acid | SCHERING CORPORATION (US) | 1988-03-02 | — | — | EP | disclosed |