Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10679395 | 1.00 | LMNA (0.40) | LMNAHCAR2TSHRALDH1A1CYP3A4 | |
| SCHEMBL10684921 | 0.89 | LMNA (0.46) | LMNAHCAR2ALDH1A1CYP3A4TDP1 | |
| SCHEMBL10684914 | 0.89 | LMNA (0.46) | LMNAHCAR2ALDH1A1CYP3A4TDP1 | |
| SCHEMBL10683996 | 0.84 | HCAR2 (0.42) | LMNAHCAR2TSHRALDH1A1CYP3A4 | |
| SCHEMBL10683990 | 0.84 | HCAR2 (0.42) | LMNAHCAR2TSHRALDH1A1CYP3A4 | |
| SCHEMBL10679402 | 0.84 | LMNA (0.30) | LMNA | |
| SCHEMBL10679390 | 0.84 | LMNA (0.30) | LMNA | |
| SCHEMBL15482671 | 0.78 | LMNA (0.41) | LMNAHCAR2TSHRALDH1A1CYP3A4 | |
| SCHEMBL13468460 | 0.78 | LMNA (0.41) | LMNAHCAR2TSHRALDH1A1CYP3A4 | |
| SCHEMBL5452972 | 0.78 | HCAR2 (0.39) | HCAR2TSHRALDH1A1CYP3A4CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4761420-A | CARDIOVASCULAR DISORDERS | LABORATOIRES SYNTEX S.A. (FR) | 1988-08-02 | — | — | US | disclosed |
| EP-0249245-A2 | Antihypertensive dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1987-12-16 | — | — | EP | disclosed |