Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10679614 | 1.00 | SLC6A3 (0.50) | SLC6A3SLC6A2HTR2CSLC6A9SLC6A5 | |
| SCHEMBL10876719 | 1.00 | SLC6A3 (0.50) | SLC6A3SLC6A2HTR2CSLC6A9SLC6A5 | |
| SCHEMBL10679597 | 1.00 | SLC6A3 (0.50) | SLC6A3SLC6A2HTR2CSLC6A9SLC6A5 | |
| SCHEMBL10671944 | 0.88 | SLC6A3 (0.57) | SLC6A3SLC6A2SLC6A4MAOAMAOB | |
| SCHEMBL11089310 | 0.85 | SLC6A3 (0.68) | SLC6A3SLC6A2SLC6A4PARP1PARP2 | |
| SCHEMBL10678658 | 0.82 | SLC6A3 (0.52) | SLC6A3SLC6A2SLC6A4KMT2A | |
| SCHEMBL10671226 | 0.82 | SLC6A3 (0.73) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL10682722 | 0.82 | SLC6A3 (0.52) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL10672420 | 0.82 | SLC6A3 (0.73) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL10682710 | 0.82 | SLC6A3 (0.52) | SLC6A3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4785007-A | ANTIDEPRESSANTS, P | LABORATOIRES HOECHST S.A. (FR) | 1988-11-15 | — | — | US | disclosed |
| EP-0203308-A2 | 2,3- Or 3,4-diphenyl-gamma-nitrile-ester derivatives for the treatment of kidney insufficiency, and their ring-closure products as psychostimulating and antidepressive medicaments | LABORATOIRES HOECHST S.A. (FR) | 1986-12-03 | — | — | EP | disclosed |