SCHEMBL11089310

SCHEMBL11089310

O=C1NCC(c2ccc(C(F)(F)F)cc2)C1c1ccccc1

nearest known ligand 0.68

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 17/20 0.68
SLC6A2 P23975 14/20 0.59
SLC6A4 P31645 5/20 0.58
PARP1 P09874 1/20 0.44
PARP2 Q9UGN5 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11095084 0.88 SLC6A3 (0.58) SLC6A3SLC6A2SLC6A4
SCHEMBL11084875 0.87 SLC6A3 (0.81) SLC6A3SLC6A2SLC6A4
SCHEMBL11084869 0.87 SLC6A3 (0.81) SLC6A3SLC6A2SLC6A4
SCHEMBL11084872 0.87 SLC6A3 (0.81) SLC6A3SLC6A2SLC6A4
SCHEMBL10679608 0.85 SLC6A3 (0.50) SLC6A3SLC6A2SLC6A4PARP1PARP2
SCHEMBL10876719 0.85 SLC6A3 (0.50) SLC6A3SLC6A2SLC6A4PARP1PARP2
SCHEMBL10679614 0.85 SLC6A3 (0.50) SLC6A3SLC6A2SLC6A4PARP1PARP2
SCHEMBL10679597 0.85 SLC6A3 (0.50) SLC6A3SLC6A2SLC6A4PARP1PARP2
SCHEMBL11111638 0.84 SLC6A3 (0.72) SLC6A3SLC6A2SLC6A4
SCHEMBL11092197 0.84 SLC6A3 (0.72) SLC6A3SLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4443616-A Production of 3-pyrrolin-2-ones THE PURDUE FREDERICK COMPANY (US) 1984-04-17 US disclosed