Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10677472 | 0.82 | NPC1 (0.38) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL10678506 | 0.81 | CYP1A2 (0.39) | KDM4EMAPTL3MBTL1CYP1A2SMN1; SMN2 | |
| SCHEMBL10675813 | 0.81 | NAPRT (0.43) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL7384614 | 0.80 | PDE3B (0.47) | PDE3BPDE3AMCL1KDM4EALDH1A1 | |
| SCHEMBL10684504 | 0.80 | CDC7 (0.40) | KDM4EMAPTL3MBTL1CYP1A2SMN1; SMN2 | |
| SCHEMBL7384727 | 0.79 | PDE3B (0.62) | PDE3BPDE3AKDM4EHPGDHSD17B10 | |
| SCHEMBL7383615 | 0.79 | PDE3B (0.46) | PDE3BPDE3AMCL1KDM4EALDH1A1 | |
| SCHEMBL10811815 | 0.77 | PDE3B (0.51) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL7381645 | 0.77 | PDE3B (0.44) | PDE3BPDE3AMCL1KDM4EALDH1A1 | |
| SCHEMBL7380887 | 0.77 | PDE3B (0.47) | PDE3BPDE3AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4769380-A | Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-09-06 | — | — | US | disclosed |