Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10680362 | 0.86 | SRD5A2 (0.48) | MAPTLMNAALDH1A1L3MBTL1POLB | |
| SCHEMBL10682007 | 0.86 | ALDH1A1 (0.56) | MAPTLMNAALDH1A1L3MBTL1POLB | |
| SCHEMBL10684242 | 0.85 | GAA (0.49) | MAPTLMNAALDH1A1L3MBTL1POLB | |
| SCHEMBL10681674 | 0.85 | ALDH1A1 (0.50) | MAPTLMNAALDH1A1L3MBTL1POLB | |
| SCHEMBL10674925 | 0.84 | ALDH1A1 (0.53) | MAPTLMNAALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL10679716 | 0.83 | ALDH1A1 (0.52) | MAPTLMNAALDH1A1L3MBTL1POLB | |
| SCHEMBL10684544 | 0.81 | CDK5 (0.54) | MAPTLMNAALDH1A1L3MBTL1POLB | |
| SCHEMBL10680367 | 0.81 | GAA (0.43) | MAPTLMNAALDH1A1L3MBTL1POLB | |
| SCHEMBL7382511 | 0.79 | PDE3B (0.43) | MAPTLMNAALDH1A1L3MBTL1POLB | |
| SCHEMBL10675710 | 0.77 | ALDH1A1 (0.51) | MAPTLMNAALDH1A1L3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4769380-A | Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-09-06 | — | — | US | disclosed |