Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.67 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.67 |
| ▸ | DRD3 | P35462 | 2/20 | 0.67 |
| ▸ | HTR2B | P41595 | 2/20 | 0.67 |
| ▸ | MLNR | O43193 | 1/20 | 0.67 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | PGR | P06401 | 1/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10676648 | 0.95 | ADRA1A (0.73) | CYP3A4CYP2D6LMNAKCNH2MEN1 | |
| Cadaverine Tartrate SCHEMBL10675929 | 0.91 | ADRA1A (0.68) | CYP3A4CYP2D6LMNAKCNH2MEN1 | |
| Cadaverine Tartrate SCHEMBL10799297 | 0.91 | ADRA1A (0.68) | CYP3A4CYP2D6LMNAKCNH2MEN1 | |
| SCHEMBL10684438 | 0.88 | CYP3A4 (0.58) | CYP3A4CYP2D6LMNAKCNH2MEN1 | |
| SCHEMBL10683725 | 0.87 | ADRA1A (0.76) | CYP3A4CYP2D6LMNAKCNH2MEN1 | |
| SCHEMBL10795286 | 0.87 | KMT2A (0.57) | CYP3A4CYP2D6LMNAKCNH2MEN1 | |
| SCHEMBL10684374 | 0.87 | HTR2A (0.64) | CYP3A4CYP2D6LMNAKCNH2MEN1 | |
| SCHEMBL10683605 | 0.86 | SLC29A1 (0.68) | CYP3A4CYP2D6LMNAKCNH2MEN1 | |
| SCHEMBL9808176 | 0.85 | SLC29A1 (0.64) | CYP3A4CYP2D6LMNAKCNH2MEN1 | |
| SCHEMBL10686081 | 0.85 | SLC29A1 (0.59) | CYP3A4CYP2D6LMNAKCNH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4766125-A | N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-08-23 | — | — | US | disclosed |
| EP-0068544-B1 | NOVEL N-ARYL-PIPERAZINEALKANAMIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-06-03 | — | — | EP | disclosed |
| EP-0068544-A2 | Novel N-aryl-piperazinealkanamides | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-01-05 | — | — | EP | disclosed |