Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10676771 | 1.00 | TSHR (0.50) | TSHRSLC1A1KMT2AMEN1LMNA | |
| SCHEMBL10676780 | 1.00 | TSHR (0.50) | TSHRSLC1A1KMT2AMEN1LMNA | |
| SCHEMBL2398973 | 0.86 | TSHR (0.52) | TSHRSLC1A1KMT2AMEN1LMNA | |
| SCHEMBL2400840 | 0.86 | TSHR (0.52) | TSHRSLC1A1KMT2AMEN1LMNA | |
| SCHEMBL10683179 | 0.83 | TSHR (0.50) | TSHRSLC1A1KMT2AMEN1LMNA | |
| SCHEMBL6958276 | 0.83 | TSHR (0.50) | TSHRSLC1A1KMT2AMEN1LMNA | |
| SCHEMBL8092036 | 0.83 | TSHR (0.50) | TSHRSLC1A1KMT2AMEN1LMNA | |
| SCHEMBL2001692 | 0.82 | ALDH1A1 (0.39) | SLC1A1LMNAALDH1A1 | |
| SCHEMBL11004183 | 0.79 | TSHR (0.57) | TSHRSLC1A1KMT2AMEN1LMNA | |
| SCHEMBL28793446 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4789675-A | HYPOTENSIVE, ANTIISCHEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-12-06 | — | — | US | disclosed |
| CN-87100658-A | 1,4-benzoxazine derivatives, their preparation and application | — | 1987-09-09 | — | — | CN | disclosed |
| EP-0233728-A1 | 1,4-Benzoxazine derivatives their production and use | Takeda Chemical Industries, Ltd. (JP) | 1987-08-26 | — | — | EP | disclosed |