Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | HTR2B | P41595 | 3/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10680935 | 0.84 | SLC6A2 (0.54) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL15283161 | 0.79 | TSHR (0.50) | SLC6A4ADRB2ADRB1HTR1AADRB3 | |
| SCHEMBL10678364 | 0.76 | HTR1A (0.38) | SLC6A4ADRB2ADRB1HTR1AADRB3 | |
| SCHEMBL10685059 | 0.75 | MAOA (0.42) | HTR2AHTR2CHTR2BBRD4 | |
| SCHEMBL10680054 | 0.75 | MAOA (0.42) | HTR2AHTR2CHTR2B | |
| SCHEMBL10685350 | 0.74 | BRD4 (0.49) | SLC6A4ADRB2ADRB1HTR1AADRB3 | |
| SCHEMBL3324787 | 0.72 | HTR1A (0.43) | SLC6A4HTR1AHTR2CHTR2BSLC6A2 | |
| SCHEMBL3324983 | 0.72 | HTR1A (0.43) | SLC6A4HTR1AHTR2CHTR2BSLC6A2 | |
| SCHEMBL10677927 | 0.72 | HRH1 (0.49) | SLC6A4ADRB2ADRB1HTR1AADRB3 | |
| SCHEMBL3324795 | 0.72 | HTR1A (0.43) | SLC6A4HTR1AHTR2CHTR2BSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4780478-A | Aminopropoxy-chromones useful as antidepressants | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKTER HAFTUNG (DE) | 1988-10-25 | — | — | US | disclosed |
| US-4508732-A | Basic ethers useful as antidepressant agents | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-04-02 | — | — | US | disclosed |
| US-4376123-A | Hexahydroazepinyloxy-chromones useful as antidepressants | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1983-03-08 | — | — | US | disclosed |