Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | DNM2 | P50570 | 4/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LATS1 | O95835 | 1/20 | 0.41 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.41 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3797836 | 0.98 | KDM4E (0.54) | KDM4EALDH1A1SMN1; SMN2HPGDHCAR3 | |
| SCHEMBL31452231 | 0.94 | ALDH1A1 (0.53) | KDM4EALDH1A1SMN1; SMN2HPGDHCAR3 | |
| SCHEMBL15923092 | 0.89 | KDM4E (0.47) | KDM4EALDH1A1SMN1; SMN2HPGDHCAR3 | |
| SCHEMBL10670706 | 0.88 | KDM4E (0.55) | KDM4EALDH1A1SMN1; SMN2HPGDHCAR3 | |
| SCHEMBL4717189 | 0.81 | ALDH1A1 (0.47) | KDM4EALDH1A1SMN1; SMN2HPGDMEN1 | |
| SCHEMBL2343301 | 0.79 | — | — | |
| SCHEMBL11315292 | 0.78 | HRH3 (0.51) | KDM4EALDH1A1SMN1; SMN2HPGDMEN1 | |
| SCHEMBL22242100 | 0.78 | ALDH1A1 (0.53) | KDM4EALDH1A1SMN1; SMN2HPGDMEN1 | |
| SCHEMBL21527350 | 0.78 | ALDH1A1 (0.57) | KDM4EALDH1A1SMN1; SMN2HPGDMEN1 | |
| SCHEMBL18274878 | 0.77 | SMN1; SMN2 (0.59) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-55028908-A | — | — | None | — | — | JP | disclosed |
| US-4718934-A | PLANT GROWTH REGULATORS | CIBA-GEIGY CORPORATION (US) | 1988-01-12 | — | — | US | disclosed |
| EP-0096125-B1 | AMINO AND AMIDO DERIVATIVES OF CHLORO NITRO AMINO AND ALKYLAMINO PYRAZINES USEFUL AS ADJUNCTS TO RADIATION THERAPY | MERCK & CO. INC. (US) | 1987-01-07 | — | — | EP | disclosed |
| EP-0175652-A2 | 5-Acylaminopyrimidines | CIBA-GEIGY AG (CH) | 1986-03-26 | — | — | EP | disclosed |
| EP-0096125-A1 | Amino and amido derivatives of chloro nitro amino and alkylamino pyrazines useful as adjuncts to radiation therapy | MERCK & CO. INC. (US) | 1983-12-21 | — | — | EP | disclosed |
| US-4414215-A | N-Acyl derivatives of 6-alkylamino 5-chloro-3-nitropyrazinamines for radiation therapy | MERCK & CO., INC. (US) | 1983-11-08 | — | — | US | disclosed |
| JP-S5528908-A | 2,3-DICYANO-5-AMINOPYRAZINE DERIVATIVE AND ITS PREPARATION | KYOWA GAS CHEM IND CO LTD | 1980-02-29 | — | — | JP | disclosed |