Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPN | P05981 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | VCAM1 | P19320 | 11/20 | 0.42 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.38 |
| ▸ | GLRB | P48167 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.35 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9330356 | 0.82 | HPN (0.47) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL10731753 | 0.81 | MAPT (0.42) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL9350056 | 0.80 | VCAM1 (0.43) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL9158690 | 0.79 | HPN (0.44) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL6275215 | 0.76 | VCAM1 (0.48) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL4397391 | 0.76 | HPN (0.53) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL11563339 | 0.76 | MAPT (0.53) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL9163368 | 0.75 | HPN (0.46) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL10676509 | 0.74 | HPN (0.45) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL10357727 | 0.74 | HPN (0.53) | HPNMAPTALOX15SIRT5VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4755524-A | Novel phenolic thioethers as inhibitors of 5-lipoxygenase | G. D. SEARLE & CO. (US) | 1988-07-05 | — | — | US | disclosed |
| EP-0235575-A1 | Novel phenolic thioethers as inhibitors of 5-lipoxygenase | G.D. Searle & Co. (US) | 1987-09-09 | — | — | EP | disclosed |