Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.35 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10399939 | 0.81 | CYP17A1 (0.42) | SLC6A2SLC6A4SLC6A3CYP17A1 | |
| SCHEMBL27759745 | 0.76 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL2547222 | 0.69 | KCNA5 (0.65) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL253431 | 0.68 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL11800360 | 0.67 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL6160196 | 0.67 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL4559171 | 0.66 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL9633065 | 0.65 | MAPT (0.49) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL4759333 | 0.64 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL11034374 | 0.64 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4761480-A | DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1988-08-02 | — | — | US | disclosed |
| EP-0214740-A2 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1987-03-18 | — | — | EP | disclosed |
| US-4634711-A | ENZYME INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1987-01-06 | — | — | US | disclosed |