Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 4/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 6/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27963558 | 0.84 | CHRM3 (0.55) | CHRM3KCNH2CHRM2LMNACYP2D6 | |
| SCHEMBL10683962 | 0.83 | CYP1A2 (0.46) | CHRM3KCNH2CHRM2LMNACYP2D6 | |
| SCHEMBL11021099 | 0.81 | MAPT (0.52) | CHRM3KCNH2CHRM2LMNACYP2D6 | |
| SCHEMBL3350095 | 0.79 | CHRM3 (0.50) | CHRM3KCNH2CHRM2LMNACYP2D6 | |
| SCHEMBL8071145 | 0.79 | CHRM3 (0.50) | CHRM3KCNH2CHRM2LMNACYP2D6 | |
| SCHEMBL4030430 | 0.79 | MAPT (0.55) | CHRM3KCNH2CHRM2LMNACYP2D6 | |
| SCHEMBL10524246 | 0.78 | CHRM3 (0.57) | CHRM3KCNH2CHRM2LMNACYP2D6 | |
| SCHEMBL1492533 | 0.78 | SMN1; SMN2 (0.52) | CHRM3KCNH2CHRM2LMNACYP2D6 | |
| Hydrochloric Acid SCHEMBL5252883 | 0.78 | MAPT (0.53) | CHRM3KCNH2CHRM2LMNACYP2D6 | |
| SCHEMBL11306031 | 0.77 | DRD3 (0.50) | CHRM3KCNH2CHRM2LMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0139358-B1 | N6-SUBSTITUTED DIARYLALKYL ADENOSINES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | WARNER-LAMBERT COMPANY (US) | 1988-11-09 | — | — | EP | disclosed |
| EP-0251339-A2 | N6- substituted diarylalkyl adenosines, processes for their production and pharmaceutical compositions comprising the same | WARNER-LAMBERT COMPANY (US) | 1988-01-07 | — | — | EP | disclosed |
| US-4657898-A | CARDIOVACULAR AND PSYCHOLOGICAL DISORDERS, ANALGESICS, OR SEDATIVES | WARNER-LAMBERT COMPANY (US) | 1987-04-14 | — | — | US | disclosed |
| US-4657897-A | N6 -substituted adenosines for treating pain | WARNER-LAMBERT COMPANY (US) | 1987-04-14 | — | — | US | disclosed |
| EP-0139358-A2 | N6-substituted diarylalkyl adenosines, processes for their production and pharmaceutical compositions comprising the same | WARNER-LAMBERT COMPANY (US) | 1985-05-02 | — | — | EP | disclosed |