Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | CPS1 | P31327 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1506600 | 0.88 | KIF11 (0.49) | KIF11CYP11B1CYP11B2CYP1A2CYP1A1 | |
| SCHEMBL531512 | 0.84 | KIF11 (0.47) | KIF11CYP11B1CYP11B2CYP1A2CYP1A1 | |
| SCHEMBL15305003 | 0.83 | CYP11B2 (0.59) | KIF11CYP11B1CYP11B2CYP1A2CYP1A1 | |
| SCHEMBL19987450 | 0.82 | KIF11 (0.49) | KIF11CYP11B1CYP11B2CYP1A2CYP1A1 | |
| SCHEMBL28661528 | 0.82 | KIF11 (0.48) | KIF11CYP11B1CYP11B2CYP1A2CYP1A1 | |
| SCHEMBL19987447 | 0.81 | KIF11 (0.48) | KIF11CYP11B1CYP11B2CYP1A2CYP1A1 | |
| SCHEMBL3993767 | 0.80 | KIF11 (0.43) | KIF11CYP11B1CYP11B2CYP1A2CYP1A1 | |
| SCHEMBL19469679 | 0.78 | AKR1C3 (0.50) | KIF11CPS1CA1CA2 | |
| Hydrochloric Acid SCHEMBL8507684 | 0.78 | KIF11 (0.52) | KIF11CYP11B1CYP11B2CYP1A2CYP1A1 | |
| SCHEMBL5187849 | 0.78 | KIF11 (0.52) | KIF11CYP11B1CYP11B2CYP1A2CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0206021-B1 | DERIVATIVES OF 1,1,2,2-TETRAMETHYL-1,2-BIS(2-FLUORO-4-HYDROXYPHENYL) ETHANE | ASTA Pharma AG (DE) | 1988-08-10 | — | — | EP | disclosed |
| US-4745233-A | Derivatives of 1,1,2,2-tetramethyl-1,2-bis-(2-fluoro-4-hydroxyphenyl)-ethane | ASTA-WERKE AKTIENGESELLSCHAFT (DE) | 1988-05-17 | — | — | US | disclosed |
| EP-0206021-A1 | Derivatives of 1,1,2,2-tetramethyl-1,2-bis(2-fluoro-4-hydroxyphenyl) ethane | ASTA Pharma AG (DE) | 1986-12-30 | — | — | EP | disclosed |