Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.68 |
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.65 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.65 |
| ▸ | GPBAR1 | Q8TDU6 | 10/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10512475 | 0.86 | PDE10A (0.77) | PDE10ACYSLTR1CYSLTR2GPBAR1CYP1A2 | |
| SCHEMBL8802103 | 0.85 | CYSLTR1 (0.64) | PDE10ACYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL8799860 | 0.85 | PDE10A (0.60) | PDE10ACYSLTR1CYSLTR2GPBAR1CYP1A2 | |
| SCHEMBL10690965 | 0.83 | CYSLTR1 (0.76) | PDE10ACYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL10510977 | 0.82 | CYSLTR1 (0.69) | PDE10ACYSLTR1CYSLTR2GPBAR1CYP1A2 | |
| SCHEMBL810302 | 0.82 | PDE10A (0.56) | PDE10ACYSLTR1CYSLTR2GPBAR1CYP1A2 | |
| SCHEMBL10549569 | 0.82 | CYSLTR1 (0.69) | PDE10ACYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL10846145 | 0.79 | PDE10A (0.68) | PDE10ACYSLTR1CYSLTR2GPBAR1CYP1A2 | |
| SCHEMBL10512001 | 0.79 | PDE10A (0.68) | PDE10ACYSLTR1CYSLTR2GPBAR1CYP1A2 | |
| SCHEMBL10547998 | 0.79 | CYSLTR1 (1.00) | PDE10ACYSLTR1CYSLTR2GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223368-A1 | Substituted naphthalene derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-05-27 | — | — | EP | claimed |
| US-4732978-A | RESPIRATORY SYSTEM DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-03-22 | — | — | US | disclosed |
| EP-0223368-A1 | Substituted naphthalene derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-05-27 | — | — | EP | disclosed |