Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.64 |
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.63 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.60 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10686237 | 0.85 | PDE10A (0.68) | CYSLTR1GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL10512475 | 0.80 | PDE10A (0.77) | CYSLTR1GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL8799860 | 0.80 | PDE10A (0.60) | CYSLTR1GPBAR1PDE10ACYSLTR2FFAR1 | |
| SCHEMBL3422397 | 0.79 | PDE10A (0.59) | CYSLTR1GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL9637028 | 0.78 | CYSLTR1 (0.65) | CYSLTR1GPBAR1PDE10ACYSLTR2FFAR1 | |
| SCHEMBL3076102 | 0.78 | CYSLTR1 (1.00) | CYSLTR1GPBAR1PDE10ACYSLTR2FFAR1 | |
| SCHEMBL8735648 | 0.78 | CYSLTR1 (0.78) | CYSLTR1GPBAR1PDE10ACYSLTR2FFAR1 | |
| SCHEMBL8800153 | 0.78 | CYSLTR1 (0.55) | CYSLTR1GPBAR1PDE10ACYSLTR2 | |
| SCHEMBL10690965 | 0.78 | CYSLTR1 (0.76) | CYSLTR1GPBAR1PDE10ACYSLTR2FFAR1 | |
| SCHEMBL4848317 | 0.77 | CYSLTR1 (1.00) | CYSLTR1GPBAR1PDE10ACYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772594-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | Abbott Laboratories (US) | 1997-05-14 | — | — | EP | disclosed |
| US-5512581-A | ANTIINFLAMMATORY AGENT | ABBOTT LABORATORIES (US) | 1996-04-30 | — | — | US | disclosed |
| WO-1996002507-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1996-02-01 | — | — | WO | disclosed |