Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | CTSG | P08311 | 1/20 | 0.42 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
| ▸ | KLK14 | Q9P0G3 | 1/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.38 |
| ▸ | GUSB | P08236 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10691944 | 0.91 | GUSB (0.38) | PDE2ACTSGKLK7KLK14KLK5 | |
| SCHEMBL10690574 | 0.90 | PDE2A (0.51) | PDE2ACTSGKLK7KLK14KLK5 | |
| SCHEMBL10610920 | 0.88 | GUSB (0.36) | PDE2ACTSGKLK7KLK14KLK5 | |
| SCHEMBL10692316 | 0.88 | PDGFRB (0.43) | MEN1MAPTALOX15ALOX12KMT2A | |
| SCHEMBL10688930 | 0.87 | MEN1 (0.39) | MEN1MAPTALOX15ALOX12KMT2A | |
| SCHEMBL11262076 | 0.84 | EGFR (0.43) | PDE2ACTSGKLK7KLK14KLK5 | |
| SCHEMBL10689009 | 0.82 | PDE5A (0.39) | MEN1KMT2ASMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL10686656 | 0.81 | PDE2A (0.53) | PDE2ACTSGKLK7KLK14KLK5 | |
| SCHEMBL10610355 | 0.81 | PDE2A (0.40) | PDE2ACYP1A2CYP3A4KDM4EHDAC3 | |
| SCHEMBL10613330 | 0.80 | PDE5A (0.37) | PDE2AMEN1MAPTALOX15KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |