Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.40 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | CTRC | Q99895 | 1/20 | 0.40 |
| ▸ | KLK14 | Q9P0G3 | 1/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10686647 | 0.90 | PDE2A (0.42) | PDE2ACYP1A2CYP3A4KDM4EALDH1A1 | |
| SCHEMBL10610355 | 0.87 | PDE2A (0.40) | PDE2ACYP1A2CYP3A4KDM4EGAA | |
| SCHEMBL10689035 | 0.86 | ESR1 (0.42) | PDE2AGAAAMY1APDE5APDE3B | |
| SCHEMBL10690513 | 0.86 | AMY1A (0.47) | PDE2ACYP1A2CYP3A4ALDH1A1MAPK1 | |
| SCHEMBL10685926 | 0.85 | PDGFRB (0.48) | PDE2ACYP3A4KDM4EMAPK1CYP2E1 | |
| SCHEMBL10691788 | 0.85 | PDE2A (0.46) | PDE2ACYP1A2CYP3A4KDM4EALDH1A1 | |
| SCHEMBL10690462 | 0.84 | AMY1A (0.40) | CYP1A2KDM4EALDH1A1AMY1APDE5A | |
| SCHEMBL10685567 | 0.84 | GUSB (0.54) | KDM4EALDH1A1GAAHTTAMY1A | |
| SCHEMBL10691944 | 0.83 | GUSB (0.38) | PDE2AKDM4EALDH1A1MAPK1HTT | |
| SCHEMBL11237399 | 0.82 | PDE2A (0.51) | PDE2ACYP1A2CYP3A4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |