Benzoic Acid

Benzoic Acid

SCHEMBL1068865

Nc1ccccc1C(O)CCO.O=C(O)c1ccccc1.O=C(O)c1ccccc1

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D

The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAO P14920 1/20 0.44
TSHR P16473 1/20 0.44
NAPRT Q6XQN6 1/20 0.44
SRD5A2 P31213 2/20 0.39
CES2 O00748 1/20 0.39
CES1 P23141 1/20 0.39
GAA P10253 2/20 0.39
MAPT P10636 1/20 0.39
NOS2 P35228 1/20 0.37
ALDH1A1 P00352 2/20 0.37
HDAC3 O15379 1/20 0.36
MAPK1 P28482 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC2 Q92769 1/20 0.36
CSNK2A1 P68400 1/20 0.36
CDC25B P30305 3/20 0.35
CDC25A P30304 1/20 0.35
CDC25C P30307 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.34
NPC1 O15118 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3968351 0.87 CYP3A4 (0.36) TSHRMAPTNOS2ALDH1A1HDAC3
SCHEMBL2443508 0.87 CYP3A4 (0.36) TSHRMAPTNOS2ALDH1A1HDAC3
Benzoic Acid SCHEMBL5981268 0.83 DAO (0.45) DAOTSHRNAPRTSRD5A2CES2
Benzoic Acid SCHEMBL1082049 0.78 DAO (0.52) DAOTSHRNAPRTSRD5A2CES2
Benzoic Acid SCHEMBL5082799 0.78 DAO (0.52) DAOTSHRNAPRTSRD5A2CES2
Benzoic Acid SCHEMBL1080914 0.78 DAO (0.52) DAOTSHRNAPRTSRD5A2CES2
Benzoic Acid SCHEMBL28003769 0.76 TSHR (0.54) DAOTSHRNAPRTSRD5A2CES2
SCHEMBL4080822 0.75 ALDH1A1 (0.46) NAPRTGAAMAPTALDH1A1SMN1; SMN2
SCHEMBL3940465 0.73 CYP3A4 (0.41) TSHRMAPTALDH1A1HDAC3SMN1; SMN2
SCHEMBL29361993 0.73 CYP3A4 (0.41) TSHRMAPTALDH1A1HDAC3SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2454290-A1 SPHERICAL MAGNESIUM HALIDE ADDUCT, CATALYST COMPONENT AND CATALYST FOR OLEFIN POLYMERIZATION PREPARED THEREFROM China Petroleum & Chemical Corporation (CN) 2012-05-23 EP disclosed
WO-2011006278-A1 SPHERICAL MAGNESIUM HALIDE ADDUCT, CATALYST COMPONENT AND CATALYST FOR OLEFIN POLYMERIZATION PREPARED THEREFROM CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2011-01-20 WO disclosed