Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PTGIR | P43119 | 1/20 | 0.44 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978813 | 0.87 | ALDH1A1 (0.55) | LTB4R2POLBKMT2ATSHR | |
| SCHEMBL2984167 | 0.82 | NPC1 (0.53) | LTB4R2POLBALOX5KMT2AMEN1 | |
| SCHEMBL18240156 | 0.81 | NPC1 (0.54) | LTB4R2POLBKMT2AMEN1TSHR | |
| SCHEMBL12472589 | 0.81 | NPC1 (0.54) | LTB4R2POLBKMT2AMEN1TSHR | |
| SCHEMBL7643097 | 0.81 | NPC1 (0.54) | LTB4R2POLBKMT2AMEN1TSHR | |
| SCHEMBL18240146 | 0.81 | NPC1 (0.54) | LTB4R2POLBKMT2AMEN1TSHR | |
| SCHEMBL28533625 | 0.81 | NPC1 (0.54) | LTB4R2POLBKMT2AMEN1TSHR | |
| SCHEMBL9471594 | 0.80 | TRPM8 (0.52) | POLBTRPM8ALOX5MTNR1AMTNR1B | |
| SCHEMBL2205203 | 0.79 | LTB4R2 (0.52) | LTB4R2POLBKDM4EKMT2A | |
| SCHEMBL18425653 | 0.78 | LTB4R2 (0.77) | LTB4R2CYP2C8CYP2C9CYP2C19PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0270093-A2 | Lactam derivatives, processes for the preparation thereof, pharmaceutical compositions comprising the same, and the use of such derivatives for the manufacture of a medicament having valuable therapeutic properties | TANABE SEIYAKU CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |