Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 2/20 | 0.55 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.55 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.55 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.55 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.55 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.49 |
| ▸ | IDH1 | O75874 | 16/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22185863 | 0.83 | IDH1 (0.50) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL22184885 | 0.81 | IDH1 (0.59) | IDH1 | |
| SCHEMBL7499153 | 0.78 | IDH1 (0.58) | IDH1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL16695793 | 0.78 | IDH1 (0.59) | IDH1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10686783 | 0.78 | KDM4E (0.55) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL7882415 | 0.76 | GRIN2D (0.62) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL19146445 | 0.75 | GRIN2D (0.61) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL12147466 | 0.74 | ALDH1A1 (0.53) | KDM4EALDH1A1 | |
| SCHEMBL12147725 | 0.73 | ALDH1A1 (0.52) | KDM4EALDH1A1 | |
| SCHEMBL1292034 | 0.72 | GRIN2D (1.00) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4735948-A | (1H-tetrazol-5-yl)-2(1H)-quinolinones and-naphthyridones and antiallergic use thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-04-05 | — | — | US | disclosed |
| EP-0120484-B1 | (1H-TETRAZOL-5-YL)TETRAZOLO (1,5-A)-QUINOLINES AND RELATED COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-04-22 | — | — | EP | disclosed |
| EP-0120483-B1 | (1H-TETRAZOL-5-YL)-2(1H)-QUINOLINONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-04-01 | — | — | EP | disclosed |
| US-4496569-A | Antiallergic (1H-tetrazol-5-yl)tetrazolo[1,5-a]quinolines and derivatives thereof | THE DOW CHEMICAL COMPANY (US) | 1985-01-29 | — | — | US | disclosed |
| EP-0120484-A1 | (1H-tetrazol-5-yl)tetrazolo (1,5-a)-quinolines and related compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-10-03 | — | — | EP | disclosed |
| EP-0120483-A1 | (1H-tetrazol-5-yl)-2(1H)-quinolinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-10-03 | — | — | EP | disclosed |