Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | GAA | P10253 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | AXL | P30530 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | APAF1 | O14727 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16695793 | 0.88 | IDH1 (0.59) | IDH1KDM4EGAAALDH1A1PDGFRB | |
| SCHEMBL19751545 | 0.80 | DAO (0.58) | IDH1KDM4EGAAALDH1A1MAPT | |
| SCHEMBL10689448 | 0.78 | GRIN2D (0.55) | IDH1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL29891877 | 0.78 | IMPDH2 (0.51) | IDH1KDM4EGAAALDH1A1CA2 | |
| SCHEMBL1429200 | 0.78 | AXL (0.59) | KDM4EGAAALDH1A1POLBAXL | |
| SCHEMBL9269640 | 0.78 | AXL (0.64) | KDM4EGAAALDH1A1POLBAXL | |
| SCHEMBL13637016 | 0.77 | ALDH1A1 (0.53) | KDM4EGAAALDH1A1POLBPDGFRB | |
| SCHEMBL10690995 | 0.77 | KDM4E (0.43) | IDH1KDM4EGAAALDH1A1MAPT | |
| SCHEMBL8139952 | 0.76 | FLT3 (0.49) | IDH1GAAPDGFRBPDGFRAALOX15 | |
| SCHEMBL10691248 | 0.76 | DAO (0.58) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708332-B2 | Respiratory syncytial virus inhibitors | MEDIVIR AB (SE) | 2017-07-18 | — | — | US | disclosed |
| US-9708332-B2 | Respiratory syncytial virus inhibitors | MEDIVIR AB (SE) | 2017-07-18 | — | — | US | disclosed |
| WO-2015065338-A1 | QUINAZOLINE BASED RESPIRATORY SYNCYTIAL VIRUS INHIBITORS | MEDIVIR AB (SE) | 2015-05-07 | — | — | WO | disclosed |
| EP-0905133-B1 | Tetrazole derivatives as LTD4 and H1 antagonists | KOWA CO (JP) | 2002-04-24 | — | — | EP | disclosed |
| US-6121286-A | ANTILEUKOTRIENE ACTIVITY AND ANTIHISTAMINIC ACTIVITY, FOR TREATING ASTHMA; COMPOUNDS SUCH AS 6-METHOXY-3-(2-(3-(2-QUINOLYLMETHOXY)BENZYL)TETRAZOLYL)QUINOLIN-2-ONE | KOWA CO., LTD. (JP) | 2000-09-19 | — | — | US | disclosed |
| US-6117886-A | EXCELLENT ANTILEUKOTRIENE ACTIVITY AND ANTIHISTAMINIC ACTIVITY, AND IS USEFUL FOR THE PREVENTION AND TREATMENT OF, FOR EXAMPLE, ASTHMA. | KOWA CO., LTD. (JP) | 2000-09-12 | — | — | US | disclosed |
| EP-0905133-A1 | Tetrazole derivatives as LTD4 and H1 antagonists | KOWA CO. LTD. (JP) | 1999-03-31 | — | — | EP | disclosed |