SCHEMBL10690002

SCHEMBL10690002

CCCC(Br)CCCCC(=O)OC

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.50
L3MBTL1 Q9Y468 1/20 0.47
ZDHHC7 Q9NXF8 1/20 0.44
POLB P06746 1/20 0.42
POLA1 P09884 1/20 0.42
CYP3A4 P08684 1/20 0.42
ATM Q13315 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
LMNA P02545 3/20 0.42
PPARG P37231 2/20 0.42
ALDH1A1 P00352 1/20 0.42
EPHX2 P34913 1/20 0.40
PPARA Q07869 1/20 0.39
CA12 O43570 1/20 0.39
CA14 Q9ULX7 1/20 0.39
PABPC1 P11940 1/20 0.38
APOBEC3A P31941 1/20 0.38
APOBEC3G Q9HC16 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1040363 0.93 TSHR (0.50) TSHRL3MBTL1ZDHHC7POLBPOLA1
SCHEMBL18124155 0.91 ZDHHC7 (0.51) TSHRL3MBTL1ZDHHC7POLBPOLA1
SCHEMBL11456570 0.91 ZDHHC7 (0.56) TSHRL3MBTL1ZDHHC7POLBPOLA1
SCHEMBL9860092 0.91 ZDHHC7 (0.56) TSHRL3MBTL1ZDHHC7POLBPOLA1
SCHEMBL9396622 0.87 TSHR (0.52) TSHRL3MBTL1ZDHHC7CYP3A4ATM
SCHEMBL11371695 0.86 TSHR (0.48) TSHRL3MBTL1ZDHHC7POLBPOLA1
SCHEMBL1800630 0.85 L3MBTL1 (0.51) TSHRL3MBTL1ZDHHC7POLBPOLA1
SCHEMBL28795142 0.85 ZDHHC7 (0.53) TSHRL3MBTL1ZDHHC7POLBPOLA1
SCHEMBL28795149 0.84 ZDHHC7 (0.56) TSHRL3MBTL1ZDHHC7POLBPOLA1
SCHEMBL28795333 0.83 TSHR (0.46) TSHRL3MBTL1ZDHHC7POLBPOLA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4769482-A Cyano and thiocyano intermediates ELI LILLY AND COMPANY (US) 1988-09-06 US disclosed
EP-0108592-B1 LEUKOTRIENE ANTAGONISTS ELI LILLY AND COMPANY (US) 1987-09-30 EP disclosed
US-4661505-A 4-(4-ACETYL-3-HYDROXY-2-PROPYLPHENOXY) ALKANOIC ACIDS, TETRAZOLES, AND DERIVATIVES ELI LILLY AND COMPANY (US) 1987-04-28 US disclosed
EP-0108592-A1 Leukotriene antagonists ELI LILLY AND COMPANY (US) 1984-05-16 EP disclosed