Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | POLA1 | P09884 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | DGKA | P23743 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.43 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1040363 | 0.98 | TSHR (0.50) | ZDHHC7L3MBTL1TSHRCYP3A4ATM | |
| SCHEMBL11456570 | 0.96 | ZDHHC7 (0.56) | ZDHHC7L3MBTL1TSHRPPARGLMNA | |
| SCHEMBL9860092 | 0.96 | ZDHHC7 (0.56) | ZDHHC7L3MBTL1TSHRPPARGLMNA | |
| SCHEMBL10690002 | 0.91 | TSHR (0.50) | ZDHHC7L3MBTL1TSHRCYP3A4ATM | |
| SCHEMBL1800630 | 0.87 | L3MBTL1 (0.51) | ZDHHC7L3MBTL1TSHRCYP3A4ATM | |
| SCHEMBL9396622 | 0.85 | TSHR (0.52) | ZDHHC7L3MBTL1TSHRCYP3A4ATM | |
| SCHEMBL20398910 | 0.84 | TSHR (0.56) | ZDHHC7TSHRCYP3A4ATMTDP1 | |
| SCHEMBL26699402 | 0.84 | LMNA (0.52) | ZDHHC7L3MBTL1TSHRCYP3A4ATM | |
| SCHEMBL4809286 | 0.83 | ZDHHC7 (0.57) | ZDHHC7L3MBTL1TSHRPPARGLMNA | |
| SCHEMBL5052870 | 0.83 | ZDHHC7 (0.57) | ZDHHC7L3MBTL1TSHRPPARGLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016156816-A1 | 1-CYANO-PYRROLIDINE COMPOUNDS AS USP30 INHIBITORS | MISSION THERAPEUTICS LIMITED (GB) | 2016-10-06 | — | — | WO | disclosed |