Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8747214 | 0.79 | HTR1A (0.51) | PARP1HTR1AADRA1A | |
| SCHEMBL614437 | 0.73 | HTR1A (0.46) | PARP1HTR1ASLC6A2SLC6A4HRH1 | |
| SCHEMBL6677547 | 0.71 | HTR2C (0.50) | PARP1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6677544 | 0.71 | HTR2C (0.50) | PARP1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19699408 | 0.70 | SLC9A1 (0.46) | — | |
| SCHEMBL19690310 | 0.70 | SLC9A1 (0.46) | — | |
| SCHEMBL23323106 | 0.70 | CHRM5 (0.44) | PARP1HTR1A | |
| SCHEMBL6677846 | 0.70 | PARP1 (0.43) | PARP1HTR1ASLC6A2SLC6A4HRH1 | |
| SCHEMBL6677848 | 0.70 | PARP1 (0.43) | PARP1HTR1ASLC6A2SLC6A4HRH1 | |
| SCHEMBL8912822 | 0.68 | TAAR1 (0.56) | SLC6A2SLC6A4HRH1SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4751222-A | 2,3,4,5-tetrahydro-1H-3-benzazepines and CNS affecting use thereof | NOVO INDUSTRI A/S (DK) | 1988-06-14 | — | — | US | disclosed |
| EP-0200455-A2 | 2,3,4,5-tetrahydro-1H-3-benzazepines substituted in position 5 | NOVO NORDISK A/S (DK) | 1986-11-05 | — | — | EP | disclosed |