Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.61 |
| ▸ | CCR1 | P32246 | 5/20 | 0.61 |
| ▸ | CCR8 | P51685 | 5/20 | 0.61 |
| ▸ | CCR5 | P51681 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.61 |
| ▸ | MMP2 | P08253 | 2/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.61 |
| ▸ | GMNN | O75496 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | MMP9 | P14780 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | MMP8 | P22894 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5004845 | 0.87 | CCR1 (0.50) | LMNACCR1CCR8CCR5TSHR | |
| SCHEMBL5160632 | 0.78 | ALDH1A1 (0.46) | KDM4ETDP1L3MBTL1ALDH1A1HSD17B10 | |
| Phenanthroline SCHEMBL29367277 | 0.78 | CCR1 (1.00) | LMNACCR1CCR8CCR5TSHR | |
| Phenanthroline SCHEMBL29354015 | 0.78 | CCR1 (1.00) | LMNACCR1CCR8CCR5TSHR | |
| Phenanthroline SCHEMBL8312 | 0.78 | CCR1 (1.00) | LMNACCR1CCR8CCR5TSHR | |
| Phenanthroline SCHEMBL8845760 | 0.78 | CCR1 (1.00) | LMNACCR1CCR8CCR5TSHR | |
| Phenanthroline SCHEMBL22982126 | 0.76 | CCR1 (0.94) | LMNACCR1CCR8CCR5TSHR | |
| Phenanthroline SCHEMBL22462277 | 0.76 | CCR1 (0.94) | LMNACCR1CCR8CCR5TSHR | |
| Phenanthroline SCHEMBL21300488 | 0.76 | CCR1 (0.94) | LMNACCR1CCR8CCR5TSHR | |
| Phenanthroline SCHEMBL21044608 | 0.76 | CCR1 (0.94) | LMNACCR1CCR8CCR5TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254179-A2 | Tetrahydrobenzothiazoloquinolines, their preparation and use | BOEHRINGER INGELHEIM KG (DE) | 1988-01-27 | — | — | EP | claimed |
| US-4698346-A | Thiazolo[5,4-h]quinoline compounds useful as anti-allergy agents | USV PHARMACEUTICAL CORPORATION (US) | 1987-10-06 | — | — | US | disclosed |
| US-4656281-A | Imidazo quinoline compounds useful as anti-allergy agents | USV PHARMACEUTICAL CORP. (US) | 1987-04-07 | — | — | US | disclosed |
| US-4563463-A | ASTHMA | USV PHARMACEUTICAL CORP. (US) | 1986-01-07 | — | — | US | disclosed |
| US-4522947-A | Certain 1,3-oxazolo[4,5H]quinolines useful as anti-allergy agents | USV PHARMACEUTICAL CORPORATION (US) | 1985-06-11 | — | — | US | disclosed |
| EP-0090360-A2 | New quinoline and related compounds useful as anti-allergy agents | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1983-10-05 | — | — | EP | disclosed |