Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 3/20 | 0.44 |
| ▸ | PNMT | P11086 | 1/20 | 0.42 |
| ▸ | RB1 | P06400 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.41 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.41 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10694135 | 0.89 | TBXA2R (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10357320 | 0.85 | CA1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10357304 | 0.83 | MTNR1A (0.60) | CA1CA2MEN1KMT2ADRD2 | |
| SCHEMBL10465600 | 0.82 | TBXA2R (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10358272 | 0.78 | TBXA2R (0.50) | TBXA2RPTGDRPTGDR2 | |
| SCHEMBL10694138 | 0.77 | CA1 (0.65) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10464736 | 0.76 | TBXA2R (0.44) | TBXA2RMEN1LMNAKMT2APTGDR | |
| SCHEMBL10686827 | 0.76 | CA1 (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9832398 | 0.75 | PSEN1 (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10691886 | 0.75 | PSEN1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0253257-A2 | Substituted amino-5,6,7,8-tetrahydronaphthyl-oxyacetic acids, method for their preparation and their application as medicaments | BAYER AG (DE) | 1988-01-20 | — | — | EP | disclosed |