Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 11/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.39 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10620864 | 0.88 | PAK1 (0.39) | DRD2DRD4HRH4DRD1PAK1 | |
| SCHEMBL10623780 | 0.86 | DRD2 (0.45) | DRD2DRD4HRH4DRD1 | |
| SCHEMBL10674331 | 0.86 | HRH4 (0.45) | DRD2DRD4HRH4DRD1NFKB1 | |
| SCHEMBL10625744 | 0.85 | DRD2 (0.42) | DRD2DRD4HRH4DRD1PAK1 | |
| SCHEMBL10625295 | 0.82 | PAK1 (0.48) | DRD2DRD4HRH4DRD1PAK1 | |
| SCHEMBL10620876 | 0.81 | HRH4 (0.43) | DRD2DRD4HRH4DRD1PAK1 | |
| SCHEMBL10679872 | 0.81 | HRH4 (0.44) | DRD2DRD4HRH4DRD1PDE4B | |
| SCHEMBL10623807 | 0.80 | DRD2 (0.47) | DRD2DRD4HRH4DRD1 | |
| SCHEMBL10620758 | 0.79 | HRH4 (0.47) | DRD2DRD4HRH4DRD1NFKB1 | |
| SCHEMBL10675874 | 0.79 | HRH4 (0.48) | DRD2DRD4HRH4DRD1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4723007-A | ANALGESICS, ANTIPSYCHOTIC AGENTS; INTERMEDIATES FOR PROCESSING | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-02-02 | — | — | US | disclosed |
| US-4723003-A | ANTIPSYCHOTIC AGENTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-02-02 | — | — | US | disclosed |
| US-4663453-A | Benzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepines having dopamine receptor activity | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-05-05 | — | — | US | disclosed |