Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | TOP1 | P11387 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9784836 | 0.90 | LMNA (0.57) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL10692192 | 0.88 | LMNA (0.52) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL10370861 | 0.88 | LMNA (0.43) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9670966 | 0.86 | KDM4E (0.45) | LMNAKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL10694404 | 0.84 | LMNA (0.45) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL10690288 | 0.80 | LMNA (0.48) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL10369825 | 0.80 | TOP1 (0.38) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL10370052 | 0.79 | LMNA (0.41) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9669597 | 0.78 | LMNA (0.50) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL9213760 | 0.78 | LMNA (0.50) | LMNAMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0251308-A1 | 4-Quinolone-3-carboxylic-acid derivatives, process for their synthesis and pharmaceutical preparations containing them | Chemie Linz Gesellschaft m.b.H. (AT) | 1988-01-07 | — | — | EP | disclosed |