Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.40 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1069055 | 1.00 | KMT2A (0.40) | KMT2AMEN1MAPTLMNAPLIN1 | |
| SCHEMBL1069073 | 0.84 | FAAH (0.40) | KMT2AMEN1MAPTLMNAPLIN1 | |
| SCHEMBL1069075 | 0.84 | FAAH (0.40) | KMT2AMEN1MAPTLMNAPLIN1 | |
| SCHEMBL1068157 | 0.79 | MAPT (0.38) | KMT2AMEN1MAPTLMNAPLIN1 | |
| SCHEMBL1068159 | 0.79 | MAPT (0.38) | KMT2AMEN1MAPTLMNAPLIN1 | |
| SCHEMBL447320 | 0.79 | MAPT (0.46) | KMT2AMEN1MAPTLMNAPLIN1 | |
| SCHEMBL4991912 | 0.74 | NPSR1 (0.42) | KMT2AMEN1MAPTLMNAPLIN1 | |
| SCHEMBL4991906 | 0.74 | NPSR1 (0.42) | KMT2AMEN1MAPTLMNAPLIN1 | |
| SCHEMBL1063931 | 0.73 | NLRP3 (0.40) | KMT2AMEN1MAPTLMNAPOLB | |
| SCHEMBL1065726 | 0.73 | MAPT (0.40) | KMT2AMEN1MAPTLMNAPLIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274297-A1 | PYRROLIDINONE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009127546-A1 | PYRROLIDINONE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-10-22 | — | — | WO | disclosed |