Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | PNMT | P11086 | 5/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10690365 | 0.87 | CYP19A1 (0.54) | CYP19A1SIGMAR1GRIN2BHTR1A | |
| SCHEMBL10688545 | 0.87 | CYP19A1 (0.54) | CYP19A1SIGMAR1GRIN2BHTR1AGBA1 | |
| SCHEMBL10688752 | 0.85 | SIGMAR1 (0.53) | CYP19A1SIGMAR1GRIN2BHTR1AGBA1 | |
| SCHEMBL9746568 | 0.81 | CYP19A1 (0.70) | CYP19A1SIGMAR1GRIN2BHTR1AGBA1 | |
| SCHEMBL29378300 | 0.76 | SLC6A4 (0.44) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL19023261 | 0.76 | SLC6A4 (0.44) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL24214091 | 0.74 | PNMT (0.59) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL3090923 | 0.74 | PNMT (0.57) | CYP19A1CYP11B2PNMTADRA2AADRA2B | |
| SCHEMBL3090915 | 0.74 | PNMT (0.57) | CYP19A1CYP11B2PNMTADRA2AADRA2B | |
| SCHEMBL8217425 | 0.74 | PNMT (0.59) | PNMTADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4738972-A | Hypoglycemic thiazolidinediones | PFIZER INC. (US) | 1988-04-19 | — | — | US | disclosed |