Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.63 |
| ▸ | PNMT | P11086 | 1/20 | 0.58 |
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | DBH | P09172 | 1/20 | 0.39 |
| ▸ | CTSG | P08311 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29025294 | 0.85 | TAAR1 (0.57) | TAAR1PNMTIDO1KDM4EALDH1A1 | |
| SCHEMBL9828207 | 0.82 | TAAR1 (0.63) | TAAR1PNMTIDO1KDM4EALDH1A1 | |
| SCHEMBL1046729 | 0.81 | PNMT (0.62) | TAAR1PNMTIDO1KDM4EALDH1A1 | |
| SCHEMBL1046520 | 0.81 | TAAR1 (0.60) | TAAR1PNMTIDO1ALDH1A1SMN1; SMN2 | |
| SCHEMBL16414477 | 0.78 | CYP1A2 (0.54) | TAAR1PNMTIDO1KDM4ECYP1A2 | |
| SCHEMBL8082929 | 0.77 | TAAR1 (0.63) | TAAR1PNMTIDO1KDM4EALDH1A1 | |
| SCHEMBL2963562 | 0.77 | TAAR1 (0.63) | TAAR1PNMTIDO1KDM4EALDH1A1 | |
| SCHEMBL5584502 | 0.77 | TAAR1 (0.63) | TAAR1PNMTIDO1KDM4EALDH1A1 | |
| SCHEMBL16404689 | 0.77 | TAAR1 (0.63) | TAAR1PNMTIDO1KDM4EALDH1A1 | |
| SCHEMBL3001711 | 0.77 | TAAR1 (0.63) | TAAR1PNMTIDO1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107735082-A | Derivatives for the treatment of muscle atrophy | 蒙塔博瑞恩研究公司 | 2018-02-23 | — | — | CN | claimed |
| CN-107735082-A | Derivatives for the treatment of muscle atrophy | 蒙塔博瑞恩研究公司 | 2018-02-23 | — | — | CN | disclosed |
| US-4727073-A | CEREBOVASCULAR DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-02-23 | — | — | US | disclosed |
| US-4698340-A | TREATMENT OF CEREBROVASCULAR DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-10-06 | — | — | US | disclosed |
| EP-0177287-A2 | Pyrimidine derivatives, processes for preparation thereof and composition of the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-04-09 | — | — | EP | disclosed |
| EP-0169712-A2 | New pyrimidine derivatives, processes for preparation thereof and composition containing the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-29 | — | — | EP | disclosed |