Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 4/20 | 0.74 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.74 |
| ▸ | HTR3B | O95264 | 2/20 | 0.74 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.74 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.74 |
| ▸ | HTR5A | P47898 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mezacopride SCHEMBL678003 | 0.90 | HTR3A (0.75) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Mezacopride SCHEMBL1802144 | 0.90 | HTR3A (0.75) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Mezacopride SCHEMBL9601284 | 0.90 | HTR3A (0.75) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Mezacopride SCHEMBL7278137 | 0.90 | HTR3A (0.75) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Mezacopride SCHEMBL10517254 | 0.89 | MAPK1 (0.74) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Hydrochloric Acid SCHEMBL7278968 | 0.88 | MAPK1 (0.71) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| (R)Zacopride SCHEMBL5387843 | 0.85 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Zacopride SCHEMBL16003 | 0.85 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Zacopride SCHEMBL29567897 | 0.85 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Zacopride SCHEMBL5373467 | 0.85 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4717563-A | 2-alkoxy-N-(1-azabicyclo(2.2.2)oct-3-yl) benzamides and thiobenzamides in a method for alleviating emesis caused by non-platinum anticancer drugs | A. H. ROBINS COMPANY, INC. (US) | 1988-01-05 | — | — | US | disclosed |