Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 10/20 | 0.70 |
| ▸ | CYSLTR2 | Q9NS75 | 7/20 | 0.70 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.64 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.64 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.64 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.58 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10446560 | 0.91 | CYSLTR1 (0.79) | CYSLTR1CYSLTR2ALOX5APALOX5FFAR1 | |
| SCHEMBL10690965 | 0.90 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2ALOX5APALOX5FFAR1 | |
| SCHEMBL8645015 | 0.89 | CYSLTR1 (0.57) | CYSLTR1CYSLTR2ALOX5APALOX5FFAR1 | |
| SCHEMBL9150476 | 0.88 | CYSLTR1 (0.72) | CYSLTR1CYSLTR2ALOX5APALOX5FFAR1 | |
| SCHEMBL10446852 | 0.88 | CYSLTR1 (0.75) | CYSLTR1CYSLTR2ALOX5APALOX5FFAR1 | |
| SCHEMBL8799848 | 0.88 | ALOX5 (0.70) | CYSLTR1CYSLTR2ALOX5APALOX5FFAR1 | |
| SCHEMBL9459951 | 0.87 | CYSLTR1 (0.67) | CYSLTR1CYSLTR2ALOX5APALOX5FFAR1 | |
| Ammonia Solution, Strong SCHEMBL9585183 | 0.86 | CYSLTR1 (0.69) | CYSLTR1CYSLTR2ALOX5FFAR1AKR1B1 | |
| SCHEMBL8666314 | 0.86 | CYSLTR1 (0.72) | CYSLTR1CYSLTR2ALOX5FFAR1AKR1B1 | |
| SCHEMBL10638887 | 0.86 | CYSLTR1 (0.69) | CYSLTR1CYSLTR2ALOX5FFAR1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5783586-A | Heteroarylmethoxyphenylthioalkyl carboxylates as inhibitors of leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1998-07-21 | — | — | US | disclosed |
| EP-0772594-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | Abbott Laboratories (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996002507-A1 | IMINOXYCARBOXYLATES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1996-02-01 | — | — | WO | disclosed |