Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 5/20 | 0.54 |
| ▸ | ATP4B | P51164 | 5/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9747346 | 0.85 | ATP4A (0.72) | ATP4AATP4BMAPK1CYP1A2CYP3A4 | |
| SCHEMBL10689756 | 0.84 | ATP4A (0.55) | ATP4AATP4BMAPK1CYP1A2CYP3A4 | |
| SCHEMBL10686609 | 0.84 | ATP4A (0.74) | ATP4AATP4BMAPK1CYP1A2CYP3A4 | |
| Iodide SCHEMBL10692587 | 0.77 | CYP1A2 (0.33) | ATP4AATP4BMAPK1CYP1A2MAPT | |
| Iodide SCHEMBL9747136 | 0.76 | ATP4A (0.58) | ATP4AATP4BMAPK1CYP1A2CYP3A4 | |
| Iodide SCHEMBL9746633 | 0.76 | ATP4A (0.55) | ATP4AATP4BMAPK1CYP1A2CYP3A4 | |
| Iodide SCHEMBL10864032 | 0.75 | ATP4A (0.57) | ATP4AATP4BMAPK1CYP1A2CYP3A4 | |
| Iodide SCHEMBL9746631 | 0.73 | PSEN1 (0.63) | ATP4AATP4BMAPK1CYP1A2CYP3A4 | |
| Iodide SCHEMBL9746994 | 0.73 | ATP4A (0.57) | ATP4AATP4BMAPK1CYP1A2CYP3A4 | |
| Iodide SCHEMBL9747520 | 0.72 | CYP1A2 (0.53) | ATP4AATP4BMAPK1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4738967-A | Imidazoisoquinoline compounds useful as anti-ulcerative agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-04-19 | — | — | US | disclosed |
| US-4686227-A | Imidazoisoquinoline compounds useful as anti-ulcerative agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-08-11 | — | — | US | disclosed |
| EP-0165545-A2 | Imidazoisoquinoline compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-12-27 | — | — | EP | disclosed |