SCHEMBL10691274

SCHEMBL10691274

COC(=O)C(C)Oc1ccc(Oc2ncc(C(F)(F)F)cc2C(F)(F)F)cc1

nearest known ligand 0.59

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.49
KMT2A Q03164 3/20 0.49
MAPT P10636 3/20 0.49
MEN1 O00255 2/20 0.49
L3MBTL1 Q9Y468 2/20 0.49
MAPK1 P28482 1/20 0.46
SMN1; SMN2 Q16637 6/20 0.46
ALDH1A1 P00352 3/20 0.46
LIPE Q05469 1/20 0.44
ATM Q13315 1/20 0.43
FFAR1 O14842 1/20 0.42
HPGD P15428 1/20 0.40
POLB P06746 1/20 0.39
HTT P42858 1/20 0.39
KDM4E B2RXH2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9359751 0.89 LMNA (0.49) LMNAKMT2AMAPTMEN1L3MBTL1
SCHEMBL8577702 0.89 LMNA (0.49) LMNAKMT2AMAPTMEN1L3MBTL1
SCHEMBL10689404 0.88 SMN1; SMN2 (0.48) LMNAKMT2AMAPTMEN1SMN1; SMN2
Haloxyfop-P-Methyl SCHEMBL54547 0.88 LMNA (0.65) LMNAKMT2AMAPTMEN1L3MBTL1
Haloxyfop-P-Methyl SCHEMBL29514646 0.88 LMNA (0.65) LMNAKMT2AMAPTMEN1L3MBTL1
Haloxyfop-P-Methyl SCHEMBL29370417 0.88 LMNA (0.65) LMNAKMT2AMAPTMEN1L3MBTL1
Haloxyfop-P-Methyl SCHEMBL54814 0.88 LMNA (0.65) LMNAKMT2AMAPTMEN1L3MBTL1
SCHEMBL11374768 0.84 SMN1; SMN2 (0.47) LMNAKMT2AMAPTMEN1SMN1; SMN2
SCHEMBL11005832 0.81 PPARG (0.49) LMNAKMT2AMEN1SMN1; SMN2ALDH1A1
SCHEMBL27514961 0.81 MAPT (0.51) KMT2AMAPTMEN1L3MBTL1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4753673-A GRASSY WEEDS THE DOW CHEMICAL COMPANY (US) 1988-06-28 US disclosed
US-4628099-A INTERMEDIATES FOR HERBICIDES THE DOW CHEMICAL COMPANY (US) 1986-12-09 US disclosed
US-4551170-A Herbicidal trifluoromethyl pyridinyloxyphenoxy and pyridinylthiophenoxy propanols and derivatives thereof THE DOW CHEMICAL COMPANY (US) 1985-11-05 US disclosed
US-4523017-A REACTING CHLORIDE SUBSTITUTED PYRIDINE COMPOUND WITH SUBSTITUTED PHENOL COMPOUND THE DOW CHEMICAL COMPANY (US) 1985-06-11 US disclosed
US-4491468-A Herbicidal trifluoromethyl pyridinyloxyphenoxy and pyridinylthiophenoxy propanenitriles and derivatives thereof THE DOW CHEMICAL COMPANY (US) 1985-01-01 US disclosed
US-4479001-A Trifluoromethyl pyridinylthiophenoxy propanoic acids and propanols and derivatives thereof THE DOW CHEMICAL COMPANY (US) 1984-10-23 US disclosed
EP-0000483-B1 TRIFLUOROMETHYL PYRIDINYL(OXY/THIO)PHENOXY PROPANOIC ACIDS AND PROPANOLS AND DERIVATIVES THEREOF THE DOW CHEMICAL COMPANY (US) 1981-10-14 EP disclosed
EP-0000483-A1 Trifluoromethyl pyridinyl(oxy/thio)phenoxy propanoic acids and propanols and derivatives thereof THE DOW CHEMICAL COMPANY (US) 1979-02-07 EP disclosed