Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17850538 | 0.80 | RAB9A (0.47) | RAB9ANPC1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL17591345 | 0.77 | RAB9A (0.44) | RAB9ANPC1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4010935 | 0.77 | NPC1 (0.50) | RAB9ANPC1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL27478783 | 0.75 | LMNA (0.44) | RAB9ANPC1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL878312 | 0.74 | CYP2D6 (0.53) | RAB9ANPC1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5472549 | 0.74 | RAB9A (0.55) | RAB9ANPC1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6351605 | 0.74 | RAB9A (0.45) | RAB9ANPC1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL29296549 | 0.73 | NPC1 (0.47) | RAB9ANPC1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7023577 | 0.73 | RAB9A (0.47) | RAB9ANPC1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL27514450 | 0.73 | NPC1 (0.63) | RAB9ANPC1SMN1; SMN2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4721794-A | Substituted thiophene-2-sulfonamide antiglaucoma agents | MERCK & CO., INC. (US) | 1988-01-26 | — | — | US | disclosed |