Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | P2RY10 | O00398 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | DGKA | P23743 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12723403 | 0.86 | CYP4F2 (0.56) | APPALDH1A1TDP1SMN1; SMN2CYP4F2 | |
| SCHEMBL19737385 | 0.85 | APP (0.57) | APPALDH1A1TDP1P2RY10ESR1 | |
| SCHEMBL23019185 | 0.83 | APP (0.57) | APPALDH1A1TDP1P2RY10HSD17B10 | |
| SCHEMBL1903256 | 0.81 | ALDH1A1 (0.43) | APPALDH1A1TDP1P2RY10HSD17B10 | |
| SCHEMBL10900609 | 0.80 | LMNA (0.58) | APPALDH1A1TDP1L3MBTL1P2RY10 | |
| SCHEMBL28968060 | 0.80 | TDP1 (0.53) | ALDH1A1TDP1L3MBTL1P2RY10SMN1; SMN2 | |
| SCHEMBL1905900 | 0.80 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1TSHR | |
| SCHEMBL584536 | 0.79 | APP (0.43) | APPALDH1A1TDP1L3MBTL1GLA | |
| SCHEMBL18843960 | 0.77 | TDP1 (0.56) | APPALDH1A1TDP1L3MBTL1P2RY10 | |
| SCHEMBL1905729 | 0.77 | NPC1 (0.41) | APPALDH1A1SMN1; SMN2CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268625-A1 | OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF | Bayer Schering Pharma Aktiengesellschaft (DE) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009127338-A1 | OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-10-22 | — | — | WO | disclosed |