E319

E319

SCHEMBL10691852

CC(=O)O.CC(C)(C)c1cc(O)ccc1O

nearest known ligand 0.80

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of E319. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 known ✓ P03372 1/20 0.44
ESR2 known ✓ Q92731 1/20 0.44
ALDH1A1 P00352 5/20 0.80
ALOX15 P16050 2/20 0.80
NR1I2 O75469 1/20 0.80
LMNA P02545 1/20 0.80
CYP2C9 P11712 1/20 0.80
MIF P14174 1/20 0.80
TYR P14679 1/20 0.80
HTT P42858 1/20 0.80
NFE2L2 Q16236 1/20 0.80
HSD17B10 Q99714 1/20 0.80
RARB P10826 2/20 0.54
RARG P13631 2/20 0.54
RARA P10276 1/20 0.54
GAA P10253 1/20 0.53
ESRRA P11474 2/20 0.50
KDM4E B2RXH2 1/20 0.48
CYP1A2 P05177 1/20 0.48
MAPT P10636 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
E319 SCHEMBL28322336 0.91 ALDH1A1 (0.67) ALDH1A1ALOX15NR1I2LMNACYP2C9
E319 SCHEMBL9392306 0.90 ALDH1A1 (0.91) ALDH1A1ALOX15NR1I2LMNACYP2C9
E319 SCHEMBL26745 0.89 ALDH1A1 (1.00) ALDH1A1ALOX15NR1I2LMNACYP2C9
E319 SCHEMBL29350903 0.89 ALDH1A1 (1.00) ALDH1A1ALOX15NR1I2LMNACYP2C9
E319 SCHEMBL27469266 0.89 ALDH1A1 (1.00) ALDH1A1ALOX15NR1I2LMNACYP2C9
E319 SCHEMBL29350899 0.89 ALDH1A1 (0.69) ALDH1A1ALOX15NR1I2LMNACYP2C9
E319 SCHEMBL18940889 0.87 ALDH1A1 (0.95) ALDH1A1ALOX15NR1I2LMNACYP2C9
E319 SCHEMBL18941443 0.87 ALDH1A1 (0.95) ALDH1A1ALOX15NR1I2LMNACYP2C9
E319 SCHEMBL10908851 0.87 ALDH1A1 (0.95) ALDH1A1ALOX15NR1I2LMNACYP2C9
E319 SCHEMBL10908842 0.87 ALDH1A1 (0.95) ALDH1A1ALOX15NR1I2LMNACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0252765-A2 Poly (ethylene oxide) stripping agents for photographic products EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1988-01-13 EP disclosed
EP-0134695-B1 PHOTOGRAPHIC ELEMENT CONTAINING A 4-HYDROXYALKYL-SUBSTITUTED 1-PHENYL-3-PYRAZOLIDINONE ELECTRON TRANSFER AGENT EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1987-09-30 EP disclosed
US-4695526-A Poly(ethylene oxide) stripping agents for photographic products EASTMAN KODAK COMPANY (US) 1987-09-22 US disclosed
EP-0177190-A2 Photographic element containing a reflecting agent in yellow dye image-providingmaterial layer EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1986-04-09 EP disclosed
EP-0078742-B1 TIMING LAYERS FOR COLOR DIFFUSION TRANSFER PHOTOGRAPHIC RECORDING MATERIALS CONTAINING POSITIVE-WORKING REDOX DYE-RELEASING COMPOUNDS EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1986-01-08 EP disclosed
US-4542087-A FILTERS; GOOD COLOR REPRODUCTION; COLOR FILMS EASTMAN KODAK COMPANY (US) 1985-09-17 US disclosed
EP-0068878-B1 USE OF OXALIC ACID IN COLOR DIFFUSION TRANSFER ASSEMBLAGES EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1985-09-11 EP disclosed
EP-0057508-B1 PHOTOSENSITIVE/FILM UNIT CONTAINING ZINC COMPOUND TO INCREASE DYE STABILITY EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1985-04-10 EP disclosed
EP-0134695-A1 Photographic element containing a 4-hydroxyalkyl-substituted 1-phenyl-3-pyrazolidinone electron transfer agent EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1985-03-20 EP disclosed
US-4504570-A Direct reversal emulsions and photographic elements useful in image transfer film units EASTMAN KODAK COMPANY (US) 1985-03-12 US disclosed
EP-0068878-A2 Use of oxalic acid in color diffusion transfer assemblages EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1983-01-05 EP disclosed
US-4357408-A NEUTRALIZATION; MASKING EASTMAN KODAK COMPANY (US) 1982-11-02 US disclosed
US-4357392-A TIMING LAYER HAVING HIGH-SPEED PERMEABILITY OF DEVELOPER; ANOTHER HAVING LOW-SPEED; COLOR FILMS; SILVER HALIDE EMULSIONS EASTMAN KODAK COMPANY (US) 1982-11-02 US disclosed
US-4357409-A NEUTRALIZATION, MASKING EASTMAN KODAK COMPANY (US) 1982-11-02 US disclosed
US-4356250-A REDOX SYSTEMS, PHOTOSTABILITY EASTMAN KODAK COMPANY (US) 1982-10-26 US disclosed
US-4353973-A MINIMIZATION OF SENSITOMETRIC CHANGES WITH KEEPING EASTMAN KODAK COMPANY (US) 1982-10-12 US disclosed
EP-0057508-A1 Photosensitive/film unit containing zinc compound to increase dye stability EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1982-08-11 EP disclosed
EP-0053010-A1 Acidic adhesive compositions and image recording products containing same EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1982-06-02 EP disclosed
EP-0045480-A1 Timing layers for color diffusion transfer assemblages EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1982-02-10 EP disclosed
US-4314020-A Color transfers assemblages with two timing layers and a neutralizing layer EASTMAN KODAK COMPANY (US) 1982-02-02 US disclosed