Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.60 |
| ▸ | CES1 | P23141 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.52 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.52 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27003688 | 0.87 | LIG1 (0.51) | CES2CES1MEN1KMT2ATP53 | |
| SCHEMBL8962602 | 0.86 | SMN1; SMN2 (0.63) | CES2CES1MEN1KMT2ATP53 | |
| SCHEMBL10341585 | 0.84 | CES2 (0.60) | CES2CES1MEN1KMT2ATP53 | |
| SCHEMBL6632890 | 0.84 | TP53 (0.68) | CES2CES1MEN1KMT2ATP53 | |
| SCHEMBL30092627 | 0.84 | TSHR (0.56) | CES2CES1MEN1KMT2ATP53 | |
| SCHEMBL11068069 | 0.83 | TSHR (0.69) | CES2CES1MEN1KMT2ATP53 | |
| SCHEMBL3571556 | 0.83 | MEN1 (0.63) | CES2CES1MEN1KMT2ATP53 | |
| SCHEMBL30192262 | 0.83 | NPC1 (0.63) | CES2CES1MEN1KMT2ATP53 | |
| SCHEMBL4254988 | 0.83 | NPC1 (0.63) | CES2CES1MEN1KMT2ATP53 | |
| SCHEMBL29964351 | 0.83 | TSHR (0.59) | CES2CES1MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4783472-A | 1H,3H-pyrrol[1,2-c]thiazole derivatives and pharmaceutical compositions containing them | RHONE-POULENC SANTE (FR) | 1988-11-08 | — | — | US | disclosed |