SCHEMBL10692066

SCHEMBL10692066

CCOC(=O)C1=C(C)NC(CC)=C(C(=O)OCC)C1c1cc([N+](=O)[O-])ccc1OCCCCNCC(O)COc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1C Q13936 11/20 0.44
ALDH1A1 P00352 1/20 0.44
ALOX12 P18054 1/20 0.44
RAB9A P51151 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
CACNA1F O60840 10/20 0.44
CACNA1D Q01668 10/20 0.44
CACNA1S Q13698 10/20 0.44
ADRA2A P08913 1/20 0.43
ADRA2B P18089 1/20 0.43
ADRA2C P18825 1/20 0.43
ADORA3 P0DMS8 1/20 0.41
HIF1A Q16665 3/20 0.41
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
CYP1A2 P05177 2/20 0.41
CYP3A4 P08684 2/20 0.41
CYP2C9 P11712 2/20 0.41
CYP2C19 P33261 2/20 0.41
MAPT P10636 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10692129 0.95 CACNA1C (0.49) CACNA1CALDH1A1ALOX12RAB9ASMN1; SMN2
SCHEMBL10688609 0.93 ADRA2A (0.50) CACNA1CALDH1A1ALOX12RAB9ASMN1; SMN2
SCHEMBL10694141 0.91 ADRA2A (0.47) CACNA1CALDH1A1ALOX12RAB9ASMN1; SMN2
SCHEMBL9485278 0.90 CACNA1C (0.43) CACNA1CALDH1A1ALOX12RAB9ASMN1; SMN2
SCHEMBL9689815 0.89 ADRA2A (0.49) CACNA1CALDH1A1ALOX12SMN1; SMN2CACNA1F
SCHEMBL9826022 0.89 ADRA2A (0.49) CACNA1CALDH1A1ALOX12SMN1; SMN2CACNA1F
SCHEMBL9824742 0.89 ADRA2A (0.49) CACNA1CALDH1A1ALOX12SMN1; SMN2CACNA1F
SCHEMBL10692431 0.89 ADRA2A (0.49) CACNA1CALDH1A1ALOX12SMN1; SMN2CACNA1F
Hydrochloric Acid SCHEMBL10689374 0.89 ADRA2A (0.51) CACNA1CALDH1A1ALOX12SMN1; SMN2CACNA1F
SCHEMBL9824640 0.89 ADRA2A (0.49) CACNA1CALDH1A1ALOX12SMN1; SMN2CACNA1F

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4727082-A CARDIOVASCULAR DISORDERS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1988-02-23 US disclosed