Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | IDO1 | P14902 | 3/20 | 0.46 |
| ▸ | TTK | P33981 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2886575 | 0.87 | IDO1 (0.56) | KDM4EALDH1A1NPC1TP53RAB9A | |
| SCHEMBL27956844 | 0.79 | IDO1 (0.61) | KDM4EALDH1A1NPC1TP53RAB9A | |
| SCHEMBL6588566 | 0.74 | KDM4E (0.58) | KDM4EALDH1A1CYP1A2GAAIDO1 | |
| SCHEMBL11786969 | 0.70 | LRRK2 (0.76) | KDM4EALDH1A1NPC1TP53RAB9A | |
| SCHEMBL2896639 | 0.70 | ITK (0.49) | TTKLRRK2AURKAITKPLK4 | |
| SCHEMBL8365109 | 0.70 | MKNK1 (0.60) | KDM4EALDH1A1NPC1TP53RAB9A | |
| SCHEMBL1672674 | 0.69 | IDO1 (0.78) | KDM4EALDH1A1NPC1TP53RAB9A | |
| SCHEMBL4220824 | 0.69 | AXL (0.49) | KDM4EALDH1A1RAB9AGAAHPGD | |
| SCHEMBL1023212 | 0.69 | CYP1A2 (0.63) | KDM4EALDH1A1NPC1TP53RAB9A | |
| SCHEMBL9041896 | 0.67 | CYP1A2 (0.61) | KDM4EALDH1A1NPC1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0120483-B1 | (1H-TETRAZOL-5-YL)-2(1H)-QUINOLINONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-04-01 | — | — | EP | claimed |
| EP-0120483-A1 | (1H-tetrazol-5-yl)-2(1H)-quinolinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-10-03 | — | — | EP | claimed |
| US-4735948-A | (1H-tetrazol-5-yl)-2(1H)-quinolinones and-naphthyridones and antiallergic use thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-04-05 | — | — | US | disclosed |
| EP-0120483-A1 | (1H-tetrazol-5-yl)-2(1H)-quinolinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-10-03 | — | — | EP | disclosed |