Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 10/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499608 | 0.78 | KDR (0.60) | DAOPDGFRBFGFR1KDR | |
| SCHEMBL10692085 | 0.78 | DAO (0.52) | DAOPARP1PDGFRBFGFR1KDR | |
| SCHEMBL8696998 | 0.75 | DAO (0.59) | DAORIPK1AURKAPARP1CCNB2 | |
| SCHEMBL7084448 | 0.74 | FGFR1 (0.70) | DAOPDGFRBFGFR1KDRCDK1 | |
| SCHEMBL7502994 | 0.74 | DAO (0.41) | DAOPARP1PDGFRBFGFR1KDR | |
| Hydrochloric Acid SCHEMBL29691618 | 0.73 | DAO (0.54) | DAORIPK1AURKAPARP1 | |
| SCHEMBL9252121 | 0.69 | DAO (0.50) | DAOPARP1PDGFRBFGFR1KDR | |
| SCHEMBL7502200 | 0.69 | KDR (0.40) | DAOPDGFRBFGFR1KDR | |
| SCHEMBL10691644 | 0.69 | DAO (0.50) | DAOPDGFRBFGFR1KDR | |
| SCHEMBL31093732 | 0.69 | DAO (0.49) | DAOAURKAPARP1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0120483-B1 | (1H-TETRAZOL-5-YL)-2(1H)-QUINOLINONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-04-01 | — | — | EP | claimed |
| EP-0120483-A1 | (1H-tetrazol-5-yl)-2(1H)-quinolinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-10-03 | — | — | EP | claimed |
| US-4735948-A | (1H-tetrazol-5-yl)-2(1H)-quinolinones and-naphthyridones and antiallergic use thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-04-05 | — | — | US | disclosed |
| EP-0120483-B1 | (1H-TETRAZOL-5-YL)-2(1H)-QUINOLINONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-04-01 | — | — | EP | disclosed |
| EP-0120483-A1 | (1H-tetrazol-5-yl)-2(1H)-quinolinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-10-03 | — | — | EP | disclosed |